Analysis of Cardiovascular Complications during Delivery Admissions Associated with COVID-19
Metabolism: Clinical and Experimental
; Conference: 20th Annual World Congress on Insulin Resistance Diabetes & Cardiovascular Disease. Universal City United States. 142(Supplement) (no pagination), 2023.
Article
in English
| EMBASE | ID: covidwho-2320762
ABSTRACT
BACKGROUND:
Persons with Coronavirus Disease 2019 (COVID-19) infection have an increased risk of pregnancy-related complications. However, data on acute cardiovascular complications during delivery admissions remain limited. OBJECTIVE(S) To determine whether birthing individuals with COVID-19 have an increased risk of acute peripartum cardiovascular complications during their delivery admission. METHOD(S) This population-based retrospective cohort study used the National Inpatient Sample (2020) by utilizing ICD-10 codes to identify delivery admissions with a diagnosis of COVID-19. A multivariable logistic regression model was developed to report an adjusted odds ratio for the association between COVID-19 and acute peripartum cardiovascular complications. RESULT(S) A total of 3,458,691 weighted delivery admissions were identified, of which 1.3% were among persons with COVID-19 (n=46,375). Persons with COVID-19 were younger (median 28 vs. 29 years, p<0.01) and had a higher prevalence of gestational diabetes mellitus (GDM), preterm births and Cesarean delivery (p<0.01). After adjustment for age, race/ethnicity, comorbidities, insurance, and income, COVID-19 remained an independent predictor of peripartum cardiovascular complications including preeclampsia (aOR 1.33 [1.29-1.37]), peripartum cardiomyopathy (aOR 2.09 [1.54-2,84]), acute coronary syndrome (ACS) (aOR 12.94 [8.85-18.90]), and cardiac arrhythmias (aOR 1.55 [1.45-1.67]) compared with no COVID-19. Likewise, the risk of in-hospital mortality, AKI, stroke, pulmonary edema, and VTE was higher with COVID-19. For resource utilization, cost of hospitalization ($5,374 vs. $4,837, p<0.01) was higher for deliveries among persons with COVID-19. CONCLUSION(S) Persons with COVID-19 had a higher risk of preeclampsia, peripartum cardiomyopathy, ACS, arrhythmias, in-hospital mortality, pulmonary edema, AKI, stroke, and VTE during delivery hospitalizations. This was associated with an increased cost of hospitalization. Keywords COVID-19, Pregnancy, GDM, PCOS, Preeclampsia, CVD, Cardiovascular Disease Abbreviations COVID-19 Coronavirus disease-2019, GDM Gestational Diabetes Mellitus, PCOS Polycystic Ovary Syndrome, National Inpatient Sample NIS, AHRQ Agency for Healthcare Research and Quality, HCUP the Healthcare Cost and Utilization Project Funding and Conflicts of Interest Dr. Michos reports Advisory Board participation for Amgen, AstraZeneca, Amarin, Bayer, Boehringer Ingelheim, Esperion, Novartis, Novo Nordisk, and Pfizer. The remaining authors have nothing to disclose.Copyright © 2023
acute coronary syndrome; adult; cardiovascular disease; cerebrovascular accident; cesarean section; cohort analysis; comorbidity; conference abstract; conflict of interest; controlled study; coronavirus disease 2019; ethnicity; female; funding; health care cost; heart arrhythmia; hospital patient; hospitalization; human; human tissue; icd-10; in-hospital mortality; insurance; lung edema; major clinical study; ovary polycystic disease; peripartum cardiomyopathy; preeclampsia; pregnancy; pregnancy diabetes mellitus; prematurity; prevalence; race; retrospective study
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Metabolism: Clinical and Experimental
Year:
2023
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS