Ultra-sensitive Detection of Alzheimer's Biosmarkers Using Plasmonic Optical Fiber Sensors
2022 Asia Communications and Photonics Conference, ACP 2022 and International Conference on Information Photonics and Optical Communications, IPOC 2022
; 2022-November:2025-2028, 2022.
Article
in English
| Scopus | ID: covidwho-2320959
ABSTRACT
The emergence of the Covid-19 pandemic has drawn great attention to vulnerable people affected by major diseases. Among them, Alzheimer's disease (AD) is the most prevalent disease. However, a long-standing challenge is to achieve early diagnosis of AD by detecting biomarkers such as amyloid beta (Aβ42), thus avoiding the labor of specialized hospital personnel and the high cost of imaging examinations using positron emission tomography. In this paper, we report a straightforward approach to realize a non-invasive lab-around fiber (LaF) optical sensor for AD biomarker detection, which is based on a tilted fiber Bragg grating (TFBG) combined with a nanoscale metallic thin film. We successfully demonstrated the detection of Aβ42 in complex biological matrices with a detection limit of 5 pg/mL. Therefore, our TFBG-SPR biosensor platform enables large-scale early disease screening and has great potential for clinical applications in early AD diagnosis. © 2022 IEEE.
Alzheimer's disease; Amyloid beta; Tilted fiber Bragg gratings; Biomarkers; Fiber Bragg gratings; Glycoproteins; Neurodegenerative diseases; Positron emission tomography; Alzheimer; Alzheimers disease; Amyloid betas; Early diagnosis; Fibre-optical sensors; High costs; Plasmonics; Sensitive detection; Tilted fiber Bragg grating; Ultrasensitive; Diagnosis
Full text:
Available
Collection:
Databases of international organizations
Database:
Scopus
Type of study:
Diagnostic study
Language:
English
Journal:
2022 Asia Communications and Photonics Conference, ACP 2022 and International Conference on Information Photonics and Optical Communications, IPOC 2022
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS