Oral glucocorticoids in multisystem inflammatory syndrome in children patients: tapering schedules, return home and risks of relapse.
Journal de Pharmacie Clinique
; 42(1):2023/11/05 00:00:00.000, 2023.
Article
in French
| EMBASE | ID: covidwho-2321002
ABSTRACT
Introduction. Pediatric Inflammatory Multisystem Syndrome (MIS-C) is treated by the administration of intravenous polyvalent immunoglobulins and corticosteroids, as recommended by the French National Authority for Health (Haute Autorite de Sante) and the WHO (World Health Organization). However, no corticosteroids tapering schedule has been validated and patients returning home are not properly supervised by a pharmacist. Aims. Identify the occurrence of relapses according to the corticosteroid tapering schedules prescribed on return home. Analyze patients' reported compliance to these decreases. Identify possible links between poor compliance and relapse. Patients and method. This retrospective study analyzes the digital medical records on Orbis software of patients who have been hospitalized for a MIS-C between April 2020 and June 2021 in a French pediatric hospital. Results. 66 MIS-C patients were included. 54 were treated by intravenous corticotherapy 2 mg/kg/day, 2 with 1 mg/kg/day, 10 have not received any. Five different tapering schedules were prescribed, 3 patients relapsed. Recurrence of relapse is not significantly related to the tapering schedule followed (p = 0,759). 6/54 (11 %) patients wrongly followed their tapering schedules. Among them, 2 relapsed, versus 1/48 (2 %) among compliers (p = 0.029;OR = 0.04). Discussion - Conclusion. This study emphasizes the difficulty for a patient to comply with corticosteroids tapering schedule without supervision, as well as the subsequent rebound risks. Pharmaceutical counseling for patients returning home after hospitalization will be promoted to ensure better communication and patients' understanding and compliance.Copyright © 2023 John Libbey Eurotext. All rights reserved.
compliance; corticotherapy; pediatric inflammatory multisystem syndrome; rebound; adult; article; controlled study; corticosteroid therapy; counseling; drug therapy; female; hospitalization; human; intravenous drug administration; major clinical study; male; medical record; pediatric hospital; pediatric multisystem inflammatory syndrome; pharmacist; relapse; retrospective study; software; World Health Organization; corticosteroid; endogenous compound; glucocorticoid; immunoglobulin
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
French
Journal:
Journal de Pharmacie Clinique
Year:
2023
Document Type:
Article
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