Acute care treatment of COVID-19 pneumonia with acute respiratory failure
Klinicka Mikrobiologie a Infekcni Lekarstvi
; 27(4)(4):135-141, 2021.
Article
in Czech
| EMBASE | ID: covidwho-2321777
ABSTRACT
Treatment of COVID-19 patients and their extreme numbers represented an unprecedented challenge for the intensive care system in healthcare facilities throughout the Czech Republic, a country particularly affected by the new coronavirus SARS-CoV-2 pandemic. A steep increase in the need for intensive care placed an excess burden on bed and staff capacity. For a severe and critical course of COVID-19, bilateral pneumonia with acute hypoxemic respiratory failure is pathognomonic. In the intensive care setting, COVID-19 therapy is primarily symptomatic, supporting failing respiratory function to gain time needed to restore it and to repair the lungs. The aggressiveness and comprehensiveness of respiratory support depend on the severity of failure, ranging from simple oxygen therapy, to non-invasive support and mechanical ventilation, to extracorporeal support. By contrast, specific COVID-19 therapy is directly targeted against SARS-CoV-2 or modulates the organism's response to the virus. Primary, virus-induced lung injury may be secondarily complicated by coinfection or superinfection, most commonly bacterial, increasing the severity and lethality of the disease. Therefore, anti-infective therapy is crucial for the prognosis and outlook of intensive care COVID-19 patients. Among nosocomial infections com-plicating COVID-19, ventilator-associated pneumonia (developing in mechanically ventilated patients) is particularly important and challenging, and so are issues related to bacterial resistance and rational antibiotic therapy.Copyright © 2021, Trios spol. s.r.o.. All rights reserved.
acute respiratory failure; antibiotic therapy; covid-19; intensive care; mechanical ventilation; pneumonia; acute hypoxemic respiratory failure; adult; adverse device effect; aggressiveness; antibiotic resistance; article; artificial ventilation; assisted ventilation; bilateral pneumonia; complication; coronavirus disease 2019; Czech Republic; emergency care; health care facility; hospital infection; human; lethality; lung injury; nonhuman; oxygen therapy; pandemic; prognosis; respiratory function; Severe acute respiratory syndrome coronavirus 2; superinfection; ventilated patient; ventilator associated pneumonia
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Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
Czech
Journal:
Klinicka Mikrobiologie a Infekcni Lekarstvi
Year:
2021
Document Type:
Article
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