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A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix.
Boldyrev, I A; Shendrikov, V P; Vostrova, A G; Vodovozova, E L.
  • Boldyrev IA; 117997 Moscow, Russia Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
  • Shendrikov VP; 117997 Moscow, Russia Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
  • Vostrova AG; 125047 Moscow, Russia Mendeleev University of Chemical Technology of Russia.
  • Vodovozova EL; 117997 Moscow, Russia Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
Russ J Bioorg Chem ; 49(2): 412-415, 2023.
Article in English | MEDLINE | ID: covidwho-2322062
ABSTRACT
The ionizable lipid ALC-0315, ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), is a component of the lipid matrix of the prophylactic SARS-CoV-2 mRNA vaccine produced by Pfizer/BioNTech. This lipid ensures efficient vaccine assembly, protects the mRNA from premature degradation, and promotes the release of the nucleic acid into the cytoplasm for its further processing after endocytosis. The present work describes a simple and economical method for the synthesis of the ALC-0315 lipid, which can be taken advantage of in mRNA vaccine production.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Russ J Bioorg Chem Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Russ J Bioorg Chem Year: 2023 Document Type: Article