[Association of neutrophil, lymphocyte, platelet ratio with acute kidney injury in sepsis]
Revista Medica del Instituto Mexicano del Seguro Social
; 61(3):342-347, 2023.
Article
in Spanish
| MEDLINE | ID: covidwho-2322124
ABSTRACT
Background:
Acute kidney injury (AKI) is frequent in sepsis (25 to 51%), with high mortality (40 to 80%) and long-term complications. Despite its importance we do not have accessible markers in intensive care. In other entities (post-surgical and COVID-19) the neutrophil/lymphocyte and platelet (N/LP) ratio has been associated with acute kidney injury;however, this relationship has not been studied in a pathology with a severe inflammatory response such as sepsis.Objective:
To demonstrate the association between N/LP with AKI secondary to sepsis in intensive care. Material andmethods:
Ambispective cohort study in patients over 18 years who were admitted to intensive care with a diagnosis of sepsis. The N/LP ratio was calculated from admission up to the seventh day and up to the diagnosis of AKI and outcome. Statistical analysis was performed with chi squared test, Cramer's V and multivariate logistic regression.Results:
Out of the 239 patients studied, the incidence of AKI developed in 70%. 80.9% of patients with N/LP ratio > 3 had AKI (p < 0.0001, Cramer's V 0.458, OR 3.05, 95% CI 1.602-5.8) and increased renal replacement therapy (21.1 vs. 11.1%, p = 0.043).Conclusion:
N/LP ratio > 3 has a moderate association with AKI secondary to sepsis in the intensive care unit. Copyright © 2023 Revista Medica del Instituto Mexicano del Seguro Social.
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Collection:
Databases of international organizations
Database:
MEDLINE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Language:
Spanish
Journal:
Revista Medica del Instituto Mexicano del Seguro Social
Year:
2023
Document Type:
Article
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