Blood Pressure, Proteases and Inhibitors
Encyclopedia of Cell Biology: Volume 1-6, Second Edition
; 1:970-976, 2022.
Article
in English
| Scopus | ID: covidwho-2322488
ABSTRACT
Blood pressure is controlled through a complex network of interacting peptide systems, principally involving the angiotensin, natriuretic peptide, endothelin and apelin families. The most complex and thoroughly investigated is the renin-angiotensin system (RAS) in which selective and potent inhibitors of the key biosynthetic proteolytic enzymes, renin and angiotensin-converting enzyme (ACE), have proved to be valuable drugs for the effective treatment of hypertension and heart failure, as well as other cardiovascular and renal disorders. Some of the other proteases in these pathways, e.g.neprilysin and ACE2, are also being explored as potential drug targets. © 2023 Elsevier Inc. All rights reserved.
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Collection:
Databases of international organizations
Database:
Scopus
Type of study:
Experimental Studies
Language:
English
Journal:
Encyclopedia of Cell Biology: Volume 1-6, Second Edition
Year:
2022
Document Type:
Article
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