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New primary immunodeficiencies 2021 context and future.
Demirdag, Yesim; Fuleihan, Ramsay; Orange, Jordan S; Yu, Joyce E.
  • Demirdag Y; Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, Irvine, CA, USA.
  • Fuleihan R; Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics.
  • Orange JS; Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics.
  • Yu JE; Division of Immunogenetics, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.
Curr Opin Pediatr ; 33(6): 657-675, 2021 12 01.
Article in English | MEDLINE | ID: covidwho-2322731
ABSTRACT
PURPOSE OF REVIEW Primary immunodeficiency diseases (PIDs), also called inborn errors of immunity (IEI), are genetic disorders classically characterized by an increased susceptibility to infection and/or disruption in the regulation of an immunologic pathway. This review summarizes and highlights the new IEI disorders in the IUIS 2019 report and 2020 interim report and discusses the directions for the future management of PIDs. RECENT

FINDINGS:

Since 2017, the International Union of Immunologic Societies (IUIS) IEI committee has updated the IUIS classification of IEIs with 88 new gene defects and 75 new immune disorders. The increased utilization of genetic testing and advances in the strategic evaluation of genetic variants have identified, not only novel IEI disorders, but additional genetic causes for known IEI disorders. Investigation of potential immune susceptibilities during the ongoing COVID-19 pandemic suggests that defects in Type I interferon signalling may underlie more severe disease.

SUMMARY:

The rapid discovery of new IEIs reflects the growing trend of applying genetic testing modalities as part of medical diagnosis and management.In turn, elucidating the pathophysiology of these novel IEIs have enhanced our understanding of how genetic mutations can modulate the immune system and their consequential effect on human health and disease.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Primary Immunodeficiency Diseases / COVID-19 / Immunologic Deficiency Syndromes Type of study: Diagnostic study / Experimental Studies Topics: Variants Limits: Humans Language: English Journal: Curr Opin Pediatr Journal subject: Pediatrics Year: 2021 Document Type: Article Affiliation country: Mop.0000000000001075

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Primary Immunodeficiency Diseases / COVID-19 / Immunologic Deficiency Syndromes Type of study: Diagnostic study / Experimental Studies Topics: Variants Limits: Humans Language: English Journal: Curr Opin Pediatr Journal subject: Pediatrics Year: 2021 Document Type: Article Affiliation country: Mop.0000000000001075