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Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients.
Dewald, Felix; Pirkl, Martin; Paluschinski, Martha; Kühn, Joachim; Elsner, Carina; Schulte, Bianca; Knüfer, Jacqueline; Ahmadov, Elvin; Schlotz, Maike; Oral, Göksu; Bernhard, Michael; Michael, Mark; Luxenburger, Maura; Andrée, Marcel; Hennies, Marc Tim; Hafezi, Wali; Müller, Marlin Maybrit; Kümpers, Philipp; Risse, Joachim; Kill, Clemens; Manegold, Randi Katrin; von Frantzki, Ute; Richter, Enrico; Emmert, Dorian; Monzon-Posadas, Werner O; Gräff, Ingo; Kogej, Monika; Büning, Antonia; Baum, Maximilian; Teipel, Finn; Mochtarzadeh, Babak; Wolff, Martin; Gruell, Henning; Di Cristanziano, Veronica; Burst, Volker; Streeck, Hendrik; Dittmer, Ulf; Ludwig, Stephan; Timm, Jörg; Klein, Florian.
  • Dewald F; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
  • Pirkl M; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
  • Paluschinski M; Institute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
  • Kühn J; Institute of Virology, Faculty of Medicine and University Hospital Muenster, University of Muenster, 48149, Muenster, Germany.
  • Elsner C; Institute for Virology, University Hospital Essen, University Duisburg-Essen, 45141, Essen, Germany.
  • Schulte B; Institute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
  • Knüfer J; German Center for Infection Research (DZIF), Partner site Bonn-Cologne, 38124, Braunschweig, Germany.
  • Ahmadov E; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
  • Schlotz M; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
  • Oral G; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
  • Bernhard M; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
  • Michael M; Emergency Department, Medical Faculty and University Hospital of Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
  • Luxenburger M; Emergency Department, Medical Faculty and University Hospital of Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
  • Andrée M; Institute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
  • Hennies MT; Institute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
  • Hafezi W; Institute of Virology, Faculty of Medicine and University Hospital Muenster, University of Muenster, 48149, Muenster, Germany.
  • Müller MM; Institute of Virology, Faculty of Medicine and University Hospital Muenster, University of Muenster, 48149, Muenster, Germany.
  • Kümpers P; Institute of Virology, Faculty of Medicine and University Hospital Muenster, University of Muenster, 48149, Muenster, Germany.
  • Risse J; Division of General Internal and Emergency Medicine, Nephrology, Hypertension and Rheumatology, Department of Medicine D, Faculty of Medicine and University Hospital Muenster, University of Muenster, 48149, Muenster, Germany.
  • Kill C; Center of Emergency Medicine, University Hospital Essen, 45147, Essen, Germany.
  • Manegold RK; Center of Emergency Medicine, University Hospital Essen, 45147, Essen, Germany.
  • von Frantzki U; Center of Emergency Medicine, University Hospital Essen, 45147, Essen, Germany.
  • Richter E; Center of Emergency Medicine, University Hospital Essen, 45147, Essen, Germany.
  • Emmert D; Institute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
  • Monzon-Posadas WO; German Center for Infection Research (DZIF), Partner site Bonn-Cologne, 38124, Braunschweig, Germany.
  • Gräff I; Institute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
  • Kogej M; Occupational Medicine Department, University Hospital Bonn, 53127, Bonn, Germany.
  • Büning A; Emergency Department, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
  • Baum M; Emergency Department, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
  • Teipel F; Institute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
  • Mochtarzadeh B; Institute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
  • Wolff M; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
  • Gruell H; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
  • Di Cristanziano V; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
  • Burst V; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
  • Streeck H; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
  • Dittmer U; Department II of Internal Medicine: Nephrology, Rheumatology, Diabetes and General Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne, 50931, Cologne, Germany.
  • Ludwig S; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
  • Timm J; Institute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
  • Klein F; German Center for Infection Research (DZIF), Partner site Bonn-Cologne, 38124, Braunschweig, Germany.
Nat Commun ; 14(1): 2835, 2023 05 19.
Article in English | MEDLINE | ID: covidwho-2322764
ABSTRACT
Determining SARS-CoV-2 immunity is critical to assess COVID-19 risk and the need for prevention and mitigation strategies. We measured SARS-CoV-2 Spike/Nucleocapsid seroprevalence and serum neutralizing activity against Wu01, BA.4/5 and BQ.1.1 in a convenience sample of 1,411 patients receiving medical treatment in the emergency departments of five university hospitals in North Rhine-Westphalia, Germany, in August/September 2022. 62% reported underlying medical conditions and 67.7% were vaccinated according to German COVID-19 vaccination recommendations (13.9% fully vaccinated, 54.3% one booster, 23.4% two boosters). We detected Spike-IgG in 95.6%, Nucleocapsid-IgG in 24.0%, and neutralization against Wu01, BA.4/5 and BQ.1.1 in 94.4%, 85.0%, and 73.8% of participants, respectively. Neutralization against BA.4/5 and BQ.1.1 was 5.6- and 23.4-fold lower compared to Wu01. Accuracy of S-IgG detection for determination of neutralizing activity against BQ.1.1 was reduced substantially. We explored previous vaccinations and infections as correlates of BQ.1.1 neutralization using multivariable and Bayesian network analyses. Given a rather moderate adherence to COVID-19 vaccination recommendations, this analysis highlights the need to improve vaccine-uptake to reduce the COVID-19 risk of immune evasive variants. The study was registered as clinical trial (DRKS00029414).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2023 Document Type: Article Affiliation country: S41467-023-38127-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2023 Document Type: Article Affiliation country: S41467-023-38127-y