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COVID-19 and low-dose radiation therapy.
Dunlap, Neal E; van Berkel, Victor; Cai, Lu.
  • Dunlap NE; Department of Radiation Oncology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
  • van Berkel V; Department of Cardiovascular and Thoracic Surgery, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
  • Cai L; Department of Radiation Oncology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Radiat Med Prot ; 2(4): 139-145, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-2322869
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of the coronavirus disease 2019 (COVID-19), has caused more than 179 million infections and 3.8 million deaths worldwide. Global health authorities working on the COVID-19 outbreak continue to explore methods to reduce the rate of its transmission to healthy individuals. Treatment protocols thus far have focused on social distancing and masking, treatment with antivirals early in infection, and steroids to reduce the inflammatory response. An alternative approach is therapy with low dose radiation (LDR), which has several advantages compared to the current drugs and medicines. To date more than 10 case reports and pilot clinical trial preliminary outcome are available from different countries. These reports cover a wide range of patient conditions and LDR treatment strategies. Although one report showed the failure to observe the improvement of COVID-19 patients after LDR therapy, the majority showed some clinical improvement, and demonstrated the safety of LDR for COVID-19 patients, particularly with 0.5 â€‹Gy. This review aims to summarize the potential rationales and mechanisms of LDR therapy for COVID-19 patients, and its current clinical status and potential use.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Randomized controlled trials Language: English Journal: Radiat Med Prot Year: 2021 Document Type: Article Affiliation country: J.radmp.2021.09.004

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Randomized controlled trials Language: English Journal: Radiat Med Prot Year: 2021 Document Type: Article Affiliation country: J.radmp.2021.09.004