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Acute hepatitis of unknown origin in children: Behind the statistics.
Elsheikh, Randa; Tien, Hoang Thuy; Makram, Abdelrahman M; Van, Nguyen Thanh; Le, Trang Thi Bich; Vasanthakumaran, Tamilarasy; Huy, Nguyen Tien.
  • Elsheikh R; Faculty of Medicine, October 6 University, Giza, Egypt.
  • Tien HT; Online Research Club, Nagasaki, Japan.
  • Makram AM; Online Research Club, Nagasaki, Japan.
  • Van NT; Faculty of Pharmacy, Da Nang University of Medical Technology and Pharmacy, Da Nang, Vietnam.
  • Le TTB; Faculty of Medicine, October 6 University, Giza, Egypt.
  • Vasanthakumaran T; Online Research Club, Nagasaki, Japan.
  • Huy NT; School of Public Health, Imperial College London, London, UK.
Hepatology ; 2022 Jul 21.
Article in English | MEDLINE | ID: covidwho-2322934
ABSTRACT
Since April 2022, the world has been witnessing a rapidly spreading outbreak of acute hepatitis of unknown origin in children < 16 years old that has affected several countries around the world. Most of the cases have presented with the clinical picture of severe hepatitis that has led to resorting to liver transplantation in several cases. Despite the numerous theories that have been suggested on the possible underlying etiologies of the outbreak, an association with hepatitis A-E viruses and a link to COVID-19 vaccines have been excluded. Adenovirus serotype 41 has been detected in numerous cases, which makes it the most likely underlying cause of the disease. Nevertheless, other hypotheses are being investigated to justify the severity of the clinical picture, which is not typical of this type of virus. This review aims to summarize the current knowledge about the outbreak, highlight the suggested working hypotheses, and report the public health measures undertaken to tackle the outbreak.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Hep.32682

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Hep.32682