COVID-19 in hemodialysis patients
Infectious Diseases: News, Opinions, Training
; 10(1):14-23, 2021.
Article
in Russian
| EMBASE | ID: covidwho-2323126
ABSTRACT
Objective. Evaluation of clinical observation, the course, the risk factors, and treatment options for SARS-CoV-2 infection in hemodialysis patients with end-stage chronic kidney disease. Material and methods. The retrospective, single-center, uncontrolled study involved 231 patients (132 M/99 W) aged 61.7+/-14.7 years with COVID-19 diagnosed. The SPSS software package was used for statistical analysis. Results. 72 (31.2%) of patients died, 68 (94.4%) of them had ARDS as the main cause of death. Comparative analysis in groups with favorable and unfavorable outcomes of the disease showed that age (68.1+/- 13.2 years vs 58.7+/-14.5 years, p<0.0001) and the comorbidity index (8.8+/-2.2 vs 6.2+/-2.6, p<0.0001) were significantly higher in those who have died compared to survivors. According to CT data, they were more likely to have 3rd or 4th-degree lung damage (72.2 vs 36.5%, p<0.0001), and the minimum oxygen saturation index 67.6+/-12.8 and 87.8+/-10.9%, respectively (p<0.0001). Somorbidity index and the need for invasive ventilation were independent predictors of the fatal outcome of COVID-19. Early administration of monoclonal antibodies to IL-6 (in the first 3 days after hospitalization) in patients with a low prevalence of the pulmonary process (CT stage 1-2) was associated with a significantly lower frequency of fatal outcome. Conclusions. SARS-CoV-2 infection in HD patients is characterized by a high rate of mortality. Predictors of severe disease in this population are comorbidity index and the need for invasive ventilation.Copyright © Infectious Diseases News, Opinions, Training.
covid-19; Hemodialysis; SARS-CoV-2; adult; adult respiratory distress syndrome; age; article; cause of death; clinical observation; comorbidity; coronavirus disease 2019; disease course; end stage renal disease/th [Therapy]; fatality; female; hemodialysis patient; hospitalization; human; invasive ventilation; lung injury; major clinical study; male; middle aged; outcome assessment; oxygen saturation; patient; prevalence; priority journal; retrospective study; risk factor; interleukin 6/ec [Endogenous Compound]; monoclonal antibody/ec [Endogenous Compound]
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Language:
Russian
Journal:
Infectious Diseases: News, Opinions, Training
Year:
2021
Document Type:
Article
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