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Functioning of the ADAMTS-13/vWF axis and its clinical significance
Obstetrics, Gynecology and Reproduction ; 17(1):127-137, 2023.
Article in Russian | EMBASE | ID: covidwho-2323372
ABSTRACT
Advances in biology have allowed us to substantially deepen our knowledge about hemostasis functioning both in health and disease. ADAMTS-13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) and von Willebrand factor (vWF) are components of the hemostasis system, which physiological interaction holds an important place in maintaining homeostasis. ADAMTS-13 is a metalloproteinase mainly acting to release vWF fragments into the blood plasma, as well as regulating its activity by cleaving ultra-large vWF multimers (UL-vWF) into smaller and less active forms. The study of such factors is of great clinical importance, since a decrease in ADAMTS-13 activity and an increase in vWF level can be predictors of microcirculatory disorders that play an important role in developing multiple organ failure. However, very few and fully contradictory studies devoted to the physiological aspects of the ADAMTS-13/vWF axis functioning in the mother-fetus system are available, therefore requiring to be further investigated.Copyright © 2023 Russian Journal of Forensic Medicine. All rights reserved.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Prognostic study Language: Russian Journal: Obstetrics, Gynecology and Reproduction Year: 2023 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Prognostic study Language: Russian Journal: Obstetrics, Gynecology and Reproduction Year: 2023 Document Type: Article