The efficiency of COVID-19 vaccines among taiwanese patients with varied comorbidities
Hepatology International
; 17(Supplement 1):S162, 2023.
Article
in English
| EMBASE | ID: covidwho-2323827
ABSTRACT
Background/Aims:
The global pandemic of COVID-19 has caused tremendous loss of human life since 2019. Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the best policies to control the pandemic. The vaccination efficacy in Taiwanese patients with different comorbidities is elusive and to be explored. Method(s) Uninfected subjects who received 3-doses of mRNA vaccines (Moderna, BioNTech), non-replicating viral vector-based vaccines (AstraZeneca, AZ) or protein subunit vaccines (Medigen COVID-19 vaccine, MVC) were prospectively enrolled. SARSCoV2- IgG spike antibody level was determined (Abbott [SARS-CoV- 2 IgG II]) within 3 months after the last dose of vaccination. Charlson Comorbidity Index (CCI) was applied to disclose the association of vaccine titer and underlying comorbidities. Result(s) A total of 824 subjects were enrolled in the current study. The mean age was 58.9 years and males accounted for 48.7% of the population. The proportion of CCI with 0-1, 2-3 and>4 was 52.8% (n = 435), 31.3% (n = 258) and 15.9% (n = 131), respectively. The most commonly used vaccination combination was AZ-AZ-Moderna (39.2%), followed by Moderna-Moderna-Moderna (27.8%) and AZAZ- BioNTech (14.7%), respectively. The mean vaccination titer was 3.11 log BAU/mL after a median 48 days of the 3rd dose. Subjects of male gender, lower body mass index, chronic kidney disease, higher CCI, and receiving AZ-AZ based vaccination were likely to have a lower titer of antibody. There was a decreasing trend of antibody titer with the increase of CCT (trend P<0.001). Linear regression analysis revealed that AZ-AZ-based vaccination (beta 0.341, 95% confidence intervals [CI] 0.144, 0.21, P<0.001) and higher CCI (beta - 0.055, CI - 0.096, - 0.014, P = 0.009) independently correlated with low IgG spike antibody levels. Conclusion(s) Patients with more comorbidities had a poor response to 3 doses of COVID-19 vaccination. Further studies are warranted to clarify the efficacy of booster vaccination in the population. The vaccine titer did not differ between patient with or without chronic liver disease.
adult; antibody titer; body mass; Charlson Comorbidity Index; chronic kidney failure; chronic liver disease; conference abstract; controlled study; coronavirus disease 2019; drug therapy; female; gender; human; immunoglobulin blood level; linear regression analysis; major clinical study; male; middle aged; prospective study; protein subunit; revaccination; SARS coronavirus 2 immunology test kit; spike; Taiwanese; vaccination; endogenous compound; immunoglobulin G; mvc-cov1901 vaccine; RNA vaccine; vector vaccine
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Vaccines
Language:
English
Journal:
Hepatology International
Year:
2023
Document Type:
Article
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