Virological, epidemiological features and prevention of SARS-CoV-2 Omicron (B.1.1.529) variant: a review
Kocaeli Universitesi Saglik Bilimleri Dergisi
; 8(3):162-171, 2022.
Article
in Turkish
| CAB Abstracts | ID: covidwho-2324035
ABSTRACT
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant Omicron (B.1.1.529) has been a cause for serious concern worldwide due to its high rate of transmission and number of mutations. During genomic studies in South Africa and Botswana in November 2021, a new variant of SARS-CoV-2 was identified associated with a rapid resurgence of infections in Gauteng Province, South Africa. Omicron variant was identified as a type of concern by the World Health Organization after sequence uploads of the first genome. It was subsequently identified in 87 countries within three weeks. The Omicron variant is a very exceptional virus carrying more than 30 mutations in the spike glycoprotein that are predicted to affect antibody neutralization and spike function. Omicron is highly contagious and spreads faster than previous variants, but may cause less severe symptoms than previous variants. Omicron variant can evade the immune system. It can also evade the vaccine responses developed against COVID-19. Rapid and careful preventive steps, including vaccination, will always be a key for suppression of the Omicron variant. This review summarizes the highly mutated regions, core infectiousness, vaccine elimination, and antibody resistance of the Omicron variant of SARSCoV-2.
Prion; Viral; Bacterial and Fungal Pathogens of Humans [VV210]; Host Resistance and Immunity [HH600]; human diseases; viral diseases; coronavirus disease 2019; disease prevalence; epidemiology; reviews; man; Severe acute respiratory syndrome coronavirus 2; Botswana; South Africa; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; ACP Countries; Anglophone Africa; Africa; Commonwealth of Nations; high Human Development Index countries; SADC Countries; Southern Africa; Africa South of Sahara; upper-middle income countries; SARS-CoV-2; viral infections; subsaharan Africa
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Observational study
/
Prognostic study
Topics:
Vaccines
/
Variants
Language:
Turkish
Journal:
Kocaeli Universitesi Saglik Bilimleri Dergisi
Year:
2022
Document Type:
Article
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