Effect of synbiotics on inflammatory markers and white blood cell count in COVID-19 patients: a randomized, double-blind, placebo-controlled clinical trial
Nutrition and Food Science
; 53(4):714-725, 2023.
Article
in English
| ProQuest Central | ID: covidwho-2324079
ABSTRACT
PurposeToday, coronavirus disease-19 (COVID-19) treatment is an evolving process, and synbiotic administration has been suggested as a new therapeutic strategy. This study aims to investigate the effect of synbiotic supplementation in COVID-19 patients.Design/methodology/approachIn this placebo-controlled trial, 80 patients were randomized to receive oral synbiotic capsule (containing fructooligosaccharide and seven bacterial strains;Lactobacillus (L) casei, L. rhamnosus, Streptococcus thermophilus, Bifidobacterium breve, L. acidophilus, Bifidobacterium longum, L. bulgaricus, each one 109 colony-forming units) or placebo for two months. Inflammatory markers (Interleukin-6 [IL-6], C-reactive protein [CRP], erythrocyte sedimentation rate [ESR]) and white blood cell (WBC) count were evaluated at two timepoints (baseline, two months later). The measured variables were adjusted for confounders and analyzed by SPSS v21.0.FindingsAll 80 enrolled patients completed the study. The study adherence was good (approximately 70%). The mean changes for IL-6 were not significant (Δ = −0.6 ± 10.4 pg/mL vs Δ = +11.2 ± 50.3 pg/mL, p > 0.05). There were no significant improvements for CRP, ESR and WBC.Originality/valueAdministration of synbiotics for two months did not improve inflammatory markers in COVID-19 patients.
Nutrition And Dietetics; Inflammation; Probiotics; COVID-19; Randomized controlled trial; Synbiotics; SARS-CoV2; Infections; Clinical trials; Blood; Plasma; Severe acute respiratory syndrome coronavirus 2; Intervention; Leukocytes; Cytokines; Erythrocyte sedimentation rate; Abdomen; Lactobacilli; Viral diseases; Interleukin 6; Lungs; C-reactive protein; Coronaviruses; Fructooligosaccharides; Patients; Diarrhea; Antibiotics; Placebos; Interleukin; Microbiota; Medical research; Tumor necrosis factor-TNF; Disease transmission
Full text:
Available
Collection:
Databases of international organizations
Database:
ProQuest Central
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Language:
English
Journal:
Nutrition and Food Science
Year:
2023
Document Type:
Article
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