Evaluation of Efficacy of the Amino Acid-Peptide Complex Administered Intragastrically to Golden Hamsters Experimentally Infected with Sars-Cov-2
Extreme Medicine
; - (2):19-25, 2021.
Article
in English
| EMBASE | ID: covidwho-2324329
ABSTRACT
The development of coronavirus infection outbreak into a pandemic, coupled with the lack of effective COVID-19 therapies, is a challenge for the entire pharmaceutical industry. This study aimed to assess the treatment and preventive efficacy of the amino acid-peptide complex (APC) in male Syrian hamsters infected with SARSCoV-2 (intranasal administration of 26 mul of the virus culture, titer of 4 x 104 TCD50/ml). In a modeled COVID-19 case, APC administered for treatment and preventive purposes reduced lung damage. Compared to the positive control group, test group had the lung weight factor 15.2% smaller (trend), which indicates a less pronounced edema. Microscopic examination revealed no alveolar edema, atypical hypertrophied forms of type II alveolocytes, pulmonary parenchyma fibrinization. The macrophage reaction intensified, which is probably a result of the APC-induced activation of regenerative processes in the lung tissues. Spleens of the animals that received APC for therapeutic and preventive purposes were less engorged and had fewer hemorrhages. The decrease of body weight of the test animals that received APC for treatment and prevention was insignificant (p < 0.05), which indicates a less severe course of COVID-19. Administered following a purely therapeutic protocol, APC proved ineffective against SARS-CoV-2 post-infection. Thus, APC-based drug used as a therapeutic and preventive agent reduces pulmonary edema and makes morphological signs of lung tissue damage less pronounced in male Syrian hamsters infected with SARS-CoV-2.Copyright © Extreme Medicine.All right reserved.
atypical pneumocytes; covid-19; pulmonary edema; Syrian hamsters; animal experiment; animal model; animal tissue; article; atelectasis; body weight loss; cell infiltration; controlled study; coronavirus disease 2019/dt [Drug Therapy]; diffuse alveolar damage; hamster model; lung alveolus cell; lung edema/dt [Drug Therapy]; lung edema/pc [Prevention]; lung hemorrhage; lung parenchyma; male; nonhuman; priority journal; Severe acute respiratory syndrome coronavirus 2; spleen; Syrian hamster; vascular lesion; virus culture; amino acid derivative/dt [Drug Therapy]; amino acid derivative/ig [Intragastric Drug Administration]; amino acid derivative/pd [Pharmacology]; unclassified drug; amino acid peptide complex/dt [Drug Therapy]; amino acid peptide complex/ig [Intragastric Drug Administration]; amino acid peptide complex/pd [Pharmacology]
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Language:
English
Journal:
Extreme Medicine
Year:
2021
Document Type:
Article
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