MERS-CoVâSpecific T-Cell Responses in Camels after Single MVA-MERS-S Vaccination.
Emerg Infect Dis
; 29(6): 1236-1239, 2023 06.
Article
in English
| MEDLINE | ID: covidwho-2324925
ABSTRACT
We developed an ELISPOT assay for evaluating Middle East respiratory syndrome coronavirus (MERS-CoV)âspecific T-cell responses in dromedary camels. After single modified vaccinia virus Ankara-MERS-S vaccination, seropositive camels showed increased levels of MERS-CoVâspecific T cells and antibodies, indicating suitability of camel vaccinations in disease-endemic areas as a promising approach to control infection.
Keywords
Dubai; ELISPOT assay; MERS-CoV; MVA; MVA expressing full-length MERS-CoV spike protein as antigen; MVA-MERS-S; Middle East respiratory syndrome coronavirus; T-cell responses; coronavirus; dromedary camels; modified vaccinia virus Ankara; respiratory infections; spike protein; vaccination; viruses; zoonoses
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coronavirus Infections
/
Middle East Respiratory Syndrome Coronavirus
Type of study:
Experimental Studies
Topics:
Vaccines
Limits:
Animals
Language:
English
Journal:
Emerg Infect Dis
Journal subject:
Communicable Diseases
Year:
2023
Document Type:
Article
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