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SARS-CoV-2 (COVID-19): What Do We Know About Children? A Systematic Review.
Mehta, Nisha S; Mytton, Oliver T; Mullins, Edward W S; Fowler, Tom A; Falconer, Catherine L; Murphy, Orla B; Langenberg, Claudia; Jayatunga, Wikum J P; Eddy, Danielle H; Nguyen-Van-Tam, Jonathan S.
  • Mehta NS; Department of Health and Social Care (England), London, United Kingdom.
  • Mytton OT; University of Cambridge, Cambridge, United Kingdom.
  • Mullins EWS; Imperial College London, London, United Kingdom.
  • Fowler TA; Obstetrics and Gynecology, Queen Charlotte's and Chelsea Hospital, London, United Kingdom.
  • Falconer CL; Genomics England, London, United Kingdom.
  • Murphy OB; Somerset County Council, Taunton, United Kingdom.
  • Langenberg C; Department of Health and Social Care (England), London, United Kingdom.
  • Jayatunga WJP; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Eddy DH; Public Health England, London, United Kingdom.
  • Nguyen-Van-Tam JS; The Francis Crick Institute, London, United Kingdom.
Clin Infect Dis ; 71(9): 2469-2479, 2020 12 03.
Article in English | MEDLINE | ID: covidwho-232507
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Child
Subject
COVID-19
Predicate
PROCESS_OF
Object
Child
2. COVID-19 AFFECTS Child
Subject
COVID-19
Predicate
AFFECTS
Object
Child
3. Disease PROCESS_OF young child
Subject
Disease
Predicate
PROCESS_OF
Object
young child
4. COVID-19 PROCESS_OF Child
Subject
COVID-19
Predicate
PROCESS_OF
Object
Child
5. COVID-19 AFFECTS Child
Subject
COVID-19
Predicate
AFFECTS
Object
Child
6. Disease PROCESS_OF young child
Subject
Disease
Predicate
PROCESS_OF
Object
young child
ABSTRACT

BACKGROUND:

Few pediatric cases of coronavirus disease 2019 (COVID-19) have been reported and we know little about the epidemiology in children, although more is known about other coronaviruses. We aimed to understand the infection rate, clinical presentation, clinical outcomes, and transmission dynamics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in order to inform clinical and public health measures.

METHODS:

We undertook a rapid systematic review and narrative synthesis of all literature relating to SARS-CoV-2 in pediatric populations. The search terms also included SARS-CoV and MERS-CoV. We searched 3 databases and the COVID-19 resource centers of 11 major journals and publishers. English abstracts of Chinese-language papers were included. Data were extracted and narrative syntheses conducted.

RESULTS:

Twenty-four studies relating to COVID-19 were included in the review. Children appear to be less affected by COVID-19 than adults by observed rate of cases in large epidemiological studies. Limited data on attack rate indicate that children are just as susceptible to infection. Data on clinical outcomes are scarce but include several reports of asymptomatic infection and a milder course of disease in young children, although radiological abnormalities are noted. Severe cases are not reported in detail and there are few data relating to transmission.

CONCLUSIONS:

Children appear to have a low observed case rate of COVID-19 but may have rates similar to adults of infection with SARS-CoV-2. This discrepancy may be because children are asymptomatic or too mildly infected to draw medical attention and be tested and counted in observed cases of COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Reviews Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Reviews Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: Cid