Host Defenses to Viruses
Clinical Immunology: Principles and Practice, Sixth Edition
; : 320-330, 2022.
Article
in English
| Scopus | ID: covidwho-2325088
ABSTRACT
Virus infections continue to pose a substantial threat to human health. A prime example is the ongoing 2019 coronavirus pandemic caused by the novel virus SARS-CoV-2. Unraveling the intricacies of immune defenses against viruses should lead to improved control of infections through the design of new vaccines and therapies. Our understanding of the fundamental cellular and molecular mechanisms involved in the immune system's response to virus infection has improved substantially in recent years. This wealth of new information and the promise of new insight from systems biology approaches continue to drive research in this field. Such knowledge has revealed why viruses sometimes induce immune dysfunction or trigger disastrous pathology and has paved the way for new therapies being tested against chronic and emerging infections. In this chapter, we briefly summarize the general concepts in immunity to virus infections and highlight some of the key challenges remaining for the future. Virus infections continue to pose a substantial threat to human health, and many cannot be controlled effectively with current vaccines or antiviral approaches. © 2023 Elsevier Ltd. All rights reserved.
Full text:
Available
Collection:
Databases of international organizations
Database:
Scopus
Type of study:
Experimental Studies
Topics:
Vaccines
Language:
English
Journal:
Clinical Immunology: Principles and Practice, Sixth Edition
Year:
2022
Document Type:
Article
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