Diagnostic value of sputum nucleic acid amplification testing for COVID-19 a meta-analysis
International Journal of Clinical and Experimental Medicine
; 16(4):75-85, 2023.
Article
in English
| EMBASE | ID: covidwho-2325251
ABSTRACT
Objective:
To systematically evaluate the diagnostic value of nucleic acid test in sputum for COVID-19 and to determine the suitable population for sputum specimens. Method(s) PubMed, CNKI, Scopus, Web of Science, medRxiv and bioRxiv databases were searched for the diagnostic value of sputum nucleic acid test for COVID-19 from December 2019 to April 2022. Two researchers independently screened the literature, extracted data, and evaluated the risk of bias with QUADAS-2 in the included studies. We used sensitivity, specificity, AUC and DOR to evaluate the diagnostic value of sputum specimens. Result(s) A total of 25 studies were included, including 10,731 subjects. Meta-analysis results showed that The combined sensitivity (SEN), specificity (SPE), diagnostic odds ratio (DOR), and area under operating characteristic curve (AUC) of sputum nucleic acid for the diagnosis of COVID-19 were 89.2% (95% CI, 86.6-91.4), 97.5% (95% CI, 97.2-97.8), 41.4 (95% CI, 11.7-145.9), 0.9474 (95% CI, 0.8964-0.9846). The results of subgroup analysis showed that the Asian group's DOR was 36.835 (95% CI, 10.83-134.570), and the Non-Asian group's DOR was 66.294 (95% CI, 0.719-6109.09). The DOR was 27.207 (95% CI, 2.860-258.780) in the OPS group and 44.165 (95% CI, 4.828-403.970) in the NPS group. DOR of mild patients was 84.255 (95% CI, 9.975-711.690), the DOR of the severe group was 14.216 (95% CI, 3.527-57.142) and was 19.464 (95% CI, 0.724-522.920) in the cured group. Conclusion(s) Current evidence shows that sputum nucleic acid test is of high diagnostic value for COVID-19. Study area and severity of disease are the influencing factors for the diagnostic accuracy of the sputum nucleic acid test. Due to the limitations on the number and quality of the included studies, the above conclusions need to be verified by more high-quality studies.Copyright © 2023, E-Century Publishing Corporation. All rights reserved.
covid-19; diagnostic value; meta-analysis; sputum; adult; controlled study; coronavirus disease 2019; COVID-19 nucleic acid testing; diagnosis; diagnostic accuracy; diagnostic test accuracy study; female; human; male; Medline; meta analysis; nucleic acid amplification techniques; Quality Assessment of Diagnostic Accuracy Studies; review; risk assessment; Scopus; sensitivity and specificity; systematic review; Web of Science; nucleic acid
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Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Diagnostic study
/
Experimental Studies
/
Prognostic study
/
Reviews
Language:
English
Journal:
International Journal of Clinical and Experimental Medicine
Year:
2023
Document Type:
Article
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