Clinical and immunological parallels in children patients with COVID-19
Infectious Diseases: News, Opinions, Training
; 11(2):25-31, 2022.
Article
in Russian
| EMBASE | ID: covidwho-2325304
ABSTRACT
The problem of the incidence of new coronavirus infection in childhood is becoming increasingly important. At the same time, questions arise regarding the peculiarities of the pathogenesis of COVID-19 in children. The aim of the research was to study the clinical and immunological features of COVID-19 in children hospitalized with a severe course of the disease. Material and methods. We examined 53 children from 0 to 15 years old, hospitalized with suspected new coronavirus infection at Children's Clinical Hospital No. 3 in Novosibirsk from October to December 2020. Determination of specific IgM and IgG antibodies to SARS-CoV-2 antigens in serum blood was carried out using the ELISA method. SARS-CoV-2 virus RNA in nasopharyngeal and oropharyngeal swabs was determined using commercial kits for PCR diagnostics. A z-test was used to compare relative numbers. The significance level was taken equal to 5% (p=0.05). Results and discussion. All examined children hospitalized with suspected COVID-19, regardless of the duration of the disease, had specific IgG antibodies to SARS-CoV-2 antigens, which confirms earlier contact with the new coronavirus in relation to the time of the examination. In 63.6% of cases, specific IgM antibodies of the class to SARS-CoV-2 were detected in the blood serum, in 6% of cases the result was doubtful. IgM antibodies were not detected in blood serum in 30.3% of patients. The results obtained for the determination of IgG and IgM antibodies to SARS-CoV-2 antigens may reflect the atypical nature of seroconversion in COVID-19. An extremely diverse clinical symptomatology was revealed, including, in addition to catarrhal syndrome and intoxication syndrome, abdominal, meningeal, and articular syndromes. In 24.3% of children, polymorphic exanthema was detected, which may be a manifestation of the systemic nature of damage to the vascular wall. Conclusion. With serologically confirmed SARS-CoV-2 etiology of the infectious process in the examined children, an extremely diverse clinical symptomatology was revealed, which, most likely, may be associated with multiple organ damage.Copyright © Transplantologiya. The Russian Journal of Transplantation.All right reserved.
antibodies; children; immunity; covid-19; SARS-CoV-2; adolescent; article; child; clinical feature; coronavirus disease 2019/di [Diagnosis]; enzyme linked immunosorbent assay; hospitalized child; human; immunology; infant; major clinical study; nasopharyngeal swab; oropharyngeal swab; pediatric patient; priority journal; protein determination; seroconversion; Severe acute respiratory syndrome coronavirus 2; symptomatology; immunoglobulin G antibody/ec [Endogenous Compound]; immunoglobulin M antibody/ec [Endogenous Compound]; virus RNA/ec [Endogenous Compound]; PCR assay kit; protein Z test kit
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Language:
Russian
Journal:
Infectious Diseases: News, Opinions, Training
Year:
2022
Document Type:
Article
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