T cells and subgroups in children with COVID-19
Kocaeli Universitesi Saglik Bilimleri Dergisi
; 8(3):239-243, 2022.
Article
in Turkish
| CAB Abstracts | ID: covidwho-2325357
ABSTRACT
Objective:
In COVID-19 disease, it was observed that T lymphocytes decreased numerically, both CD4+ and CD8+ could decrease, and sometimes the CD8+ level increased significantly. The virus-specific CD8+ T-cells are thought to be TEM or TEMRA cells. However, the characteristics of these cells, particularly their role in the pathogenesis of SARS-CoV-2 infection or COVID-19 disease, are unclear. Therefore, this study aimed to examine the flow cytometric changes observed in T helper, T cytotoxic cells, and subtypes during diagnosis in pediatric patients diagnosed with COVID-19 infection with SARS-CoV-2 PCR positivity.Methods:
Twenty-two children aged 0-18, diagnosed with COVID-19, with flow cytometry;T Helper Cell (TH), T Cytotoxic Cell (TC), T Naive Cells (TN), Central Memory (TCM), Effector Memory (TEM), RA + Effector memory (TEMRA) and Recent Thymic Emigrants (RTEs) were studied.Results:
T cell counts were found to be expected in all age groups. The CD4/CD8 ratio increased in the under-five and over 16 age group. While TCM among CD4+T cells decreased in the group above 16 years of age, TEM decreased in all age groups. RTEs decreased in all except the age group 16+. Naive CD8+ T cells (TN) were found to be high in all age groups.Conclusion:
A low number of CD4+ and CD8+ lymphocytes have been reported as a distinctive laboratory finding in 2019 Coronavirus disease (COVID-19). Having enough naive T cells is essential for the immune system to respond consistently to unknown pathogens. This study found that these cells were higher than expected in children.
Human Immunology and Allergology [VV055]; Prion; Viral; Bacterial and Fungal Pathogens of Humans [VV210]; adolescents; age groups; CD4+ lymphocytes; CD8+ lymphocytes; children; coronavirus disease 2019; human diseases; lungs; lymphocytes; respiratory diseases; T lymphocytes; viral diseases; man; Severe acute respiratory syndrome coronavirus 2; Turkey; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Mediterranean Region; OECD Countries; upper-middle income countries; very high Human Development Index countries; West Asia; Asia; teenagers; T4 lymphocytes; CD4+ cells; CD8+ cells; T8 lymphocytes; lung diseases; SARS-CoV-2; T cells; viral infections
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Experimental Studies
/
Randomized controlled trials
Language:
Turkish
Journal:
Kocaeli Universitesi Saglik Bilimleri Dergisi
Year:
2022
Document Type:
Article
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