Your browser doesn't support javascript.
Neuropathogenesis and Neurological Manifestations of SARS-CoV-2
COVID-19 Critical and Intensive Care Medicine Essentials ; : 85-100, 2022.
Article in English | Scopus | ID: covidwho-2325646
ABSTRACT
Neurological complications of COVID-19 contribute significantly to mortality in the intensive care unit (ICU). Preventive therapy, though discussed in literature, is limited for COVID-19 neurological manifestations and treatment algorithms continue to rely on evidence from previous pandemics. Thus, in this chapter we evaluate current in vitro, in vitro, histopathological studies to ascertain the most likely mechanisms of SARS-CoV-2 central nervous system entry. From this understanding, we determine probable mechanisms for neurological compilations observed in COVID-19 as relevant to the clinician. SARS-CoV-2 infection of nasal epithelium and the respiratory tract may allow for a systemic inflammatory response that results in neuroinflammation. While most neurological complications are inflammatory in etiology, rarely, SARS-CoV-2 may enter into the central nervous system and mediate neuronal damage. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
Keywords

Full text: Available Collection: Databases of international organizations Database: Scopus Type of study: Etiology study / Experimental Studies Language: English Journal: COVID-19 Critical and Intensive Care Medicine Essentials Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: Databases of international organizations Database: Scopus Type of study: Etiology study / Experimental Studies Language: English Journal: COVID-19 Critical and Intensive Care Medicine Essentials Year: 2022 Document Type: Article