Acute Fibrinous Organizing Pneumonia in a COVID-19 Patient: A Case Report
Journal of the Medical Association of Thailand
; 104(4):S123-S127, 2023.
Article
in English
| EMBASE | ID: covidwho-2325770
ABSTRACT
Background:
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has varied clinical and radiographic manifestations. Severe initial viral infection, cytokine release, opportunistic infection and post-viral inflammation may all contribute to progressive symptoms and severe lung injury. Acute fibrinous and organizing pneumonitis (AFOP), a rare pattern of acute lung injury characterized by intra-alveolar fibrin ball, has so far been reported associated with infections, connective tissue diseases, drugs and toxins, hematologic malignancy, altered immune status and inhalation injury. Case Report The authors report a case of 26-year-old man with severe COVID-19 pneumonia that clinical and radiographic imaging worsened after episode of cytokine storm. The diagnosis of AFOP was confirmed by transbronchial biopsy, and the patient was successfully treated with high-dose corticosteroids. Conclusion(s) AFOP can be found in severe COVID-19 patients especially when clinical deterioration occurs later in disease course. Clinical suspicion is needed for prompt diagnosis and treatment. High-dose corticosteroid is an effective medication.Copyright © 2023 JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND.
Acute fibrinous organizing pneumonia; Acute lung injury; Case report; covid-19; Respiratory failure; SARS-CoV-2; Viral pneumonia; adult; article; clinical article; coronavirus disease 2019; COVID-19 pneumonia; cytokine storm; deterioration; drug megadose; drug therapy; human; male; nonhuman; organizing pneumonia; pneumonia; Severe acute respiratory syndrome coronavirus 2; transbronchial biopsy; virus pneumonia; corticosteroid
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Case report
/
Prognostic study
Language:
English
Journal:
Journal of the Medical Association of Thailand
Year:
2023
Document Type:
Article
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