Convalescent plasma for COVID-19 in the intensive care unit.
Anaesthesiol Intensive Ther
; 53(5): 398-402, 2021.
Article
in English
| MEDLINE | ID: covidwho-2325899
ABSTRACT
INTRODUCTION:
We aimed to investigate the clinical features and mortality of critically ill patients treated with convalescent plasma for COVID-19 in the intensive care unit (ICU). MATERIAL ANDMETHODS:
We retrospectively collected clinical and laboratory data of COVID-19 patients treated in the ICU. The patients were divided into two groups those who received convalescent plasma and those who did not. We evaluated changes in the laboratory parameters and PaO2/FiO2 of the patients in the convalescent plasma group on days 0, 7, and 14.RESULTS:
A total of 188 patients were included, 89 of whom received convalescent plasma. There were no significant differences in length of hospitalization [median 17 vs. 16 days, P = 0.13] or 28-day mortality between the two groups (59% vs. 65%, P = 0.38). The ICU stay of patients who received convalescent plasma was longer (P = 0.001). The dynamics of the laboratory parameters of 44 patients in the convalescent plasma group, who were still in intensive care on the 14th day, were analysed. There was no differences in CRP or PaO2/FiO2 on day 0, 7 or 14 (P = 0.12; P = 0.10, respectively).CONCLUSIONS:
Convalescent plasma treatment was not associated with shorter hospitalisation or lower mortality in patients diagnosed with COVID-19. However, the ICU stay was longer in patients who received convalescent plasma.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
Language:
English
Journal:
Anaesthesiol Intensive Ther
Journal subject:
Anesthesiology
Year:
2021
Document Type:
Article
Affiliation country:
Ait.2021.111551
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