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COVID-19 vaccination, dengue hepatitis, and recurrent unilateral anterior uveitis.
Sanjay, Srinivasan; Kawali, Ankush; Mahendradas, Padmamalini.
  • Sanjay S; Department of Uveitis and Ocular immunology, Narayana Nethralaya, Bengaluru, Karnataka, India.
  • Kawali A; Department of Uveitis and Ocular immunology, Narayana Nethralaya, Bengaluru, Karnataka, India.
  • Mahendradas P; Department of Uveitis and Ocular immunology, Narayana Nethralaya, Bengaluru, Karnataka, India.
Indian J Ophthalmol ; 71(5): 2269-2272, 2023 05.
Article in English | MEDLINE | ID: covidwho-2326049
ABSTRACT
A 36-year-old Asian Indian male presented with redness and pain in his right eye of 1 week duration. He was diagnosed to have right acute anterior uveitis and had a history of being admitted at a local hospital for dengue hepatitis a month earlier. He had been on adalimumab 40 mg three weekly once and oral methotrexate 20 mg/week for human leucocyte antigen (HLA) B27 spondyloarthropathy and recurrent anterior uveitis. Our patient had re-activation of his anterior chamber inflammation on three distinct occasions first, 3 weeks following recovery from coronavirus disease 2019 (COVID-19), the second after the second dose of COVID-19 vaccination, and the third after recovery from dengue fever-associated hepatitis. We propose molecular mimicry and bystander activation as the postulated mechanisms for the re-activation of his anterior uveitis. In conclusion, patients with auto-immune diseases can have recurrent ocular inflammation following COVID-19 or its vaccination or dengue fever as seen in our patient. The anterior uveitis is usually mild and responds to topical steroids. Additional immuno-suppression may not be needed. Mild ocular inflammation following vaccination should not deter individuals from getting COVID-19 vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Uveitis / Uveitis, Anterior / Dengue / COVID-19 / Hepatitis / Hepatitis A Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Humans / Male Language: English Journal: Indian J Ophthalmol Year: 2023 Document Type: Article Affiliation country: Ijo.IJO_2064_22

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Uveitis / Uveitis, Anterior / Dengue / COVID-19 / Hepatitis / Hepatitis A Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Humans / Male Language: English Journal: Indian J Ophthalmol Year: 2023 Document Type: Article Affiliation country: Ijo.IJO_2064_22