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Can bronchial secretion cultures identify the etiologic agent of COVID-19-associated pulmonary aspergillosis in ICU patients? Comparison with a species-specific Aspergillus PCR in serum.
Siopi, Maria; Antonopoulou, Stavroula; Mantzana, Paraskevi; Georgiou, Panagiota-Christina; Vourli, Sophia; Protonotariou, Efthymia; Vagiakou, Eleni; Skoura, Lemonia; Pournaras, Spyros; Meletiadis, Joseph.
  • Siopi M; Clinical Microbiology Laboratory, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Antonopoulou S; Department of Microbiology, "G. Gennimatas" General Hospital, Athens, Greece.
  • Mantzana P; Department of Microbiology, "AHEPA" University Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Georgiou PC; Clinical Microbiology Laboratory, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Vourli S; Clinical Microbiology Laboratory, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Protonotariou E; Department of Microbiology, "AHEPA" University Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Vagiakou E; Department of Microbiology, "G. Gennimatas" General Hospital, Athens, Greece.
  • Skoura L; Department of Microbiology, "AHEPA" University Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Pournaras S; Clinical Microbiology Laboratory, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Meletiadis J; Clinical Microbiology Laboratory, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Med Mycol ; 61(1)2022 Dec 29.
Article in English | MEDLINE | ID: covidwho-2326352
ABSTRACT
Aspergillus spp. isolated from non-BAL cultures of coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) patients may reflect colonization rather than infection. Sera (n = 181) from 49 adult ICU CAPA patients (24 probable and 25 possible CAPA) with bronchial secretions (BS) culture positive for Aspergillus spp. were collected and tested for Aspergillus DNA detection by species-specific real-time PCR. Overall, 30/49 (61%) patients were PCR positive. BS culture/serum PCR agreement was moderate (21/30; 70%). Based on serum PCR positive patients, all CAPAs were due to A. fumigatus (80%), A. flavus (10%), and A. terreus (10%). No A. niger/A. nidulans or mixed infections were found despite positive BS cultures.
Discordant results were observed between bronchial secretion cultures and species-specific serum PCR (30%) with A. fumigatus being by far the most common etiological agent of CAPA (80%). No A. niger/A. nidulans or mixed infections were found despite positive cultures.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Aspergillosis / COVID-19 Type of study: Diagnostic study / Etiology study Topics: Long Covid Limits: Animals Language: English Journal subject: Veterinary Medicine / Microbiology Year: 2022 Document Type: Article Affiliation country: Mmy

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Aspergillosis / COVID-19 Type of study: Diagnostic study / Etiology study Topics: Long Covid Limits: Animals Language: English Journal subject: Veterinary Medicine / Microbiology Year: 2022 Document Type: Article Affiliation country: Mmy