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Treatment-Resistant Late-Life Depression: A Review of Clinical Features, Neuropsychology, Neurobiology, and Treatment.
Subramanian, Subha; Oughli, Hanadi A; Gebara, Marie Anne; Palanca, Ben Julian A; Lenze, Eric J.
  • Subramanian S; Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. Electronic address: ssubram5@bidmc.harvard.edu.
  • Oughli HA; Department of Psychiatry, Semel Institute for Neuroscience, University of California Los Angeles, Los Angeles, CA, USA.
  • Gebara MA; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Palanca BJA; Department of Anesthesiology, Washington University School of Medicine in St. Louis, St Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine in St. Louis, St Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine in St. Lou
  • Lenze EJ; Department of Psychiatry, Washington University School of Medicine in St. Louis, St Louis, MO, USA.
Psychiatr Clin North Am ; 46(2): 371-389, 2023 06.
Article in English | MEDLINE | ID: covidwho-2326496
ABSTRACT
Major depression is common in older adults (≥ 60 years of age), termed late-life depression (LLD). Up to 30% of these patients will have treatment-resistant late-life depression (TRLLD), defined as depression that persists despite two adequate antidepressant trials. TRLLD is challenging for clinicians, given several etiological factors (eg, neurocognitive conditions, medical comorbidities, anxiety, and sleep disruption). Proper assessment and management is critical, as individuals with TRLLD often present in medical settings and suffer from cognitive decline and other marks of accelerated aging. This article serves as an evidence-based guide for medical practitioners who encounter TRLLD in their practice.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Depression / Depressive Disorder, Major Type of study: Diagnostic study / Etiology study / Prognostic study / Qualitative research Topics: Long Covid Limits: Aged / Humans Language: English Journal: Psychiatr Clin North Am Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Depression / Depressive Disorder, Major Type of study: Diagnostic study / Etiology study / Prognostic study / Qualitative research Topics: Long Covid Limits: Aged / Humans Language: English Journal: Psychiatr Clin North Am Year: 2023 Document Type: Article