Outcomes, risk factors, and incidence of acute kidney injury in hospitalized COVID-19 patients
Iranian Red Crescent Medical Journal
; 25(2), 2023.
Article
in English
| CAB Abstracts | ID: covidwho-2326616
ABSTRACT
Background:
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV2) is the virus causing Coronavirus Disease 2019 (COVID-19). Apart from respiratory disease, this virus can affect different organs.Objectives:
Therefore, multiple mechanisms have been hypothesized for Acute Kidney Injury (AKI) in COVID-19. In this study, we evaluate the incidence and prognosis of AKI in COVID-19 patients.Methods:
This retrospective cohort study assessed 397 COVID-19 patients hospitalized between April 1, 2020, and September 30, 2021. Patients with a sudden rise of serum creatinine level, more than 0.3 mg/dl in two days or more than 50% of the initial level in one week, were diagnosed with AKI. Demographic, laboratory, and clinical features were compared in AKI patients with patients without AKI.Results:
A total of 397 patients with a mean age +or- standard deviation of 55.42 +or- 15.26 years were included in the study. According to diagnostic criteria, 48 (12.1%) patients developed AKI. Old age, a history of hypertension, and chronic renal failure were suggested as risk factors for AKI. High levels of C-Reactive Protein, Erythrocyte Sedimentation Rate, Lactate Dehydrogenase, D-dimer, and serum phosphorus upon arrival were also associated with an increased risk of AKI. In addition, the incidence of hypernatremia and hyperkalemia increased mortality in patients with AKI.Conclusion:
The incidence of AKI in admitted COVID-19 patients affects the duration of hospitalization, the chance of ICU admission, and mortality. It is important to limit the use of nephrotoxic drugs and to maintain water-electrolyte balance to prevent the incidence of AKI and improve the outcome.
Non-communicable Human Diseases and Injuries [VV600]; Prion; Viral; Bacterial and Fungal Pathogens of Humans [VV210]; creatinine; human diseases; disease incidence; epidemiology; clinical aspects; mortality; coronavirus disease 2019; risk factors; retrospective studies; cohort studies; acute course; acute infections; blood analysis; blood pressure; blood serum; blood vessels; C-reactive protein; disease course; enzymes; hypertension; lactate dehydrogenase; phosphorus; prognosis; kidney diseases; kidneys; renal failure; severe course; severe infections; Severe acute respiratory syndrome coronavirus 2; man; Iran; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; high Human Development Index countries; lower-middle income countries; Middle East; West Asia; Asia; SARS-CoV-2; clinical picture; death rate; disease progression; high blood pressure; kidney disorders; nephropathy; renal diseases; kidney failure
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Language:
English
Journal:
Iranian Red Crescent Medical Journal
Year:
2023
Document Type:
Article
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