COVID-19 in patients with myasthenia gravis.
Muscle Nerve
; 62(2): 254-258, 2020 08.
Article
in English
| MEDLINE | ID: covidwho-2209145
ABSTRACT
INTRODUCTION:
Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic, but little is known about its potential impact on patients with myasthenia gravis (MG).METHODS:
We studied the clinical course of COVID-19 in five hospitalized patients with autoimmune MG (four with acetylcholine receptor antibodies, one with muscle-specific tyrosine kinase antibodies) between April 1, 2020-April 30-2020.RESULTS:
Two patients required intubation for hypoxemic respiratory failure, whereas one required significant supplemental oxygen. One patient with previously stable MG had myasthenic exacerbation. One patient treated with tocilizumab for COVID-19 was successfully extubated. Two patients were treated for MG with intravenous immunoglobulin without thromboembolic complications.DISCUSSION:
Our findings suggest that the clinical course and outcomes in patients with MG and COVID-19 are highly variable. Further large studies are needed to define best practices and determinants of outcomes in this unique population.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Respiratory Insufficiency
/
Immunoglobulins, Intravenous
/
Coronavirus Infections
/
Antibodies, Monoclonal, Humanized
/
Immunologic Factors
/
Hypoxia
/
Myasthenia Gravis
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Muscle Nerve
Year:
2020
Document Type:
Article
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