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Liver injury in patients with COVID-19 who received dexamethasone monotherapy
Hepatology International ; 17(Supplement 1):S161, 2023.
Article in English | EMBASE | ID: covidwho-2327191
ABSTRACT

Introduction:

Liver injury is frequently seen in coronavirus disease 2019 (COVID-19), and it has been reported to be associated with the severity of COVID-19. The direct action of the virus, cytokine storm, coagulation abnormalities, drug-induced, etc. are considered to be the causes of liver injury, and antiviral agents against COVID-19 and steroids used as anti-inflammatory agents have also been reported to contribute to the appearance of liver injury. In Japan, remdesivir, dexamethasone (Dex), baricitinib, etc. are used as therapeutic agents for COVID-19, but there is still not enough evidence about the frequency of liver injury as an adverse event. Aims &

Methods:

This study aimed to clarify the influence of Dex monotherapy for liver injury in COVID-19 with respiratory failure. We examined 171 patients with COVID-19 with liver injury in the respiratory failure groups and the nonrespiratory failure groups and investigated 41 patients with moderate COVID-19 with respiratory failure who received Dex monotherapy in the liver injury group and the nonliver injury group at the time before treatment. Result(s) The respiratory failure group had 64% more liver damage than the non-respiratory failure group, was older, had more men, and had significantly more complications of lifestyle-related diseases such as hypertension and diabetes. Obesity was more common in the liver injury group prior to Dex monotherapy, and the liver CT value was significantly lower than in the non-liver injury group. Liver injury worsened in 41% of patients after Dex monotherapy, but there was no significant difference in the frequency before Dex monotherapy between the liver injury group and the non-liver injury group, and the degree of liver injury was mild in all cases, improving in 38% of the liver injury group. Conclusion(s) Dex monotherapy was a safe treatment for moderate COVID-19 with respiratory failure, which frequently resulted in liver injury.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Journal: Hepatology International Year: 2023 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Journal: Hepatology International Year: 2023 Document Type: Article