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The rise of the variants
Contemporary Pediatrics ; 40(1):21-21,26, 2023.
Article in English | ProQuest Central | ID: covidwho-2327455
ABSTRACT
Case fatality rates were lower during the Delta-dominated period than the Omicron period, however.3 Additionally, the report included the caveat that vaccination rates also increased from the period of Delta-dominated infections until Omicron took over.3 Although the US increase in the Omicron XBB variant is still relatively new, it has been significant, rising from about 4% of cases in a week to more than 40%,' dwarfing the Australian study's estimates of a weekly growth rate of around 57%.2 It is still too early to estimate the exact impact of the Omicron XBB variant, but some experts believe they have zeroed in on the source of its potency. The mechanism for higher transmis-sibility in this variant is still a mystery, but increased angiotensin-converting enzyme 2 binding in this latest variant explains its superior growth and resistance to antibodies.4 Changes to the spike protein-the major target for vaccines-and monoclonal antibodies in the XBB variant make it more immune evasive than previous Omicron variants, data from another study suggested.5 Omicron, XBB, and children Most of the data on the impact of the Omicron strains that have taken over US COVID-19 infections focus on adult patients, but some reports have estimated the impact on the pediatric population specifically. [...]he said, influenza has taken over both COVID-19 and respiratory syncytial virus (RSV) cases in his community.
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Collection: Databases of international organizations Database: ProQuest Central Topics: Vaccines / Variants Language: English Journal: Contemporary Pediatrics Year: 2023 Document Type: Article

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Collection: Databases of international organizations Database: ProQuest Central Topics: Vaccines / Variants Language: English Journal: Contemporary Pediatrics Year: 2023 Document Type: Article