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Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Nat Med ; 26(6): 842-844, 2020 06.
Article in English | MEDLINE | ID: covidwho-244490
ABSTRACT
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
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Full text: Available Database: MEDLINE Type: Article Main subject: Pneumonia, Viral / Coronavirus Infections / Single-Cell Analysis / Betacoronavirus Subject: Pneumonia, Viral / Coronavirus Infections / Single-Cell Analysis / Betacoronavirus Language: English Journal: Nat Med Year: 2020