Your browser doesn't support javascript.
Longitudinal Change of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in Patients with Coronavirus Disease 2019.
Zhang, Guoxin; Nie, Shuke; Zhang, Zhaohui; Zhang, Zhentao.
  • Zhang G; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Nie S; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Zhang Z; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Zhang Z; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
J Infect Dis ; 222(2): 183-188, 2020 06 29.
Article in English | MEDLINE | ID: covidwho-245018
Semantic information from SemMedBD (by NLM)
1. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
2. Antibodies TREATS COVID-19
Subject
Antibodies
Predicate
TREATS
Object
COVID-19
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. Antibodies TREATS Patients
Subject
Antibodies
Predicate
TREATS
Object
Patients
5. Assay USES Antibodies
Subject
Assay
Predicate
USES
Object
Antibodies
6. Negative PROCESS_OF Patients
Subject
Negative
Predicate
PROCESS_OF
Object
Patients
7. Antibodies NEG_PART_OF Patients
Subject
Antibodies
Predicate
NEG_PART_OF
Object
Patients
8. Immunoglobulin M NEG_PART_OF Patients
Subject
Immunoglobulin M
Predicate
NEG_PART_OF
Object
Patients
9. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
10. Antibodies TREATS COVID-19
Subject
Antibodies
Predicate
TREATS
Object
COVID-19
11. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
12. Antibodies TREATS Patients
Subject
Antibodies
Predicate
TREATS
Object
Patients
13. Assay USES Antibodies
Subject
Assay
Predicate
USES
Object
Antibodies
14. Negative PROCESS_OF Patients
Subject
Negative
Predicate
PROCESS_OF
Object
Patients
15. Antibodies NEG_PART_OF Patients
Subject
Antibodies
Predicate
NEG_PART_OF
Object
Patients
16. Immunoglobulin M NEG_PART_OF Patients
Subject
Immunoglobulin M
Predicate
NEG_PART_OF
Object
Patients
ABSTRACT

BACKGROUND:

A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged and caused the rapid spread of coronavirus disease 2019 (COVID-19) worldwide.

METHODS:

We did a retrospective study and included COVID-19 patients admitted to Renmin Hospital of Wuhan University between 1 February and 29 February 2020. Antibody assay was conducted to detect COVID-19 envelope protein E and nucleocapsid protein N antigen.

RESULTS:

One hundred twelve patients were recruited with symptoms of fever, cough, fatigue, myalgia, and diarrhea. All patients underwent antibody tests. Fifty-eight (51.79%) were positive for both immunoglobulin M (IgM) and immunoglobulin G (IgG), 7 (6.25%) were negative for both antibodies, 1 (0.89%) was positive for only IgM, and 46 (41.07%) were positive for only IgG. IgM antibody appeared within a week post-disease onset, lasted for 1 month, and gradually decreased, whereas IgG antibody was produced 10 days after infection and lasted for a longer time. However, no significant difference in levels of IgM and IgG antibodies between positive and negative patients of nucleic acid test after treatment was found.

CONCLUSIONS:

Our results indicate that serological tests could be a powerful approach for the early diagnosis of COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis