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SARS-CoV-2 and myocardial injury: a role for Nox2?
Violi, Francesco; Pastori, Daniele; Pignatelli, Pasquale; Cangemi, Roberto.
  • Violi F; Department of Clinical, Internal Medicine, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. francesco.violi@uniroma1.it.
  • Pastori D; Department of Clinical, Internal Medicine, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
  • Pignatelli P; Department of Clinical, Internal Medicine, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
  • Cangemi R; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Intern Emerg Med ; 15(5): 755-758, 2020 Aug.
Article in English | MEDLINE | ID: covidwho-245085
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be complicated by myocardial injury but at-risk patients as well as mechanism of disease are unclear. We gathered data regarding troponin levels in the so far reported SARS-CoV-2 patients and found a large variability in terms of troponin levels, patients with more severe disease, as those treated by ICU, presenting with higher percentage of troponin elevation. However, lack of prospective studies hampers adequate analysis of risk factors of myocardial damage. Previous study demonstrated that Nox2 is up-regulated in pneumonia and closely associated with troponin elevation suggesting Nox2 activation as mechanism eliciting myocardial damage; data in SARS-CoV-2 are still lacking. We hypothesize that SARS-Cov-2 may induce myocardial injury via Nox2-related ROS production and that analysis and eventually targeting Nox2 may be a novel approach to manage SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Heart Diseases Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Intern Emerg Med Journal subject: Emergency Medicine / Internal Medicine Year: 2020 Document Type: Article Affiliation country: S11739-020-02348-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Heart Diseases Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Intern Emerg Med Journal subject: Emergency Medicine / Internal Medicine Year: 2020 Document Type: Article Affiliation country: S11739-020-02348-6