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Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19.
Omarjee, Loukman; Janin, Anne; Perrot, Frédérique; Laviolle, Bruno; Meilhac, Olivier; Mahe, Guillaume.
  • Omarjee L; Inserm, NuMeCan Institute (UMR INSERM 1241), Rennes F-35033, France; Univ Rennes, CHU Rennes, INSERM, CIC1414, Clinical Immunology and Vascular Medicine, Rennes F-35033, France. Electronic address: loukman.omarjee@chu-rennes.fr.
  • Janin A; Inserm, (U942), Paris Diderot University, Sorbonne Paris Cité, Paris F-75018, France.
  • Perrot F; Cellular and Molecular Biology Consultant, Rennes F-35033, France.
  • Laviolle B; Inserm, Clinical Investigation Center 1414, Univ Rennes, CHU Rennes, Rennes F-35033, France.
  • Meilhac O; Reunion Island University, INSERM U1188, Diabetes atherothrombosis Réunion Indian Ocean (DéTROI), CYROI Plateform, Sainte-Clotilde F-97490, France; CHU de La Réunion, Saint-Pierre F- 97448, France.
  • Mahe G; Inserm, Clinical Investigation Center 1414, Univ Rennes, CHU Rennes, Rennes F-35033, France.
Clin Immunol ; 216: 108464, 2020 07.
Article in English | MEDLINE | ID: covidwho-245182
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cytokines / Coronavirus Infections / Sirolimus / Pandemics / Cytokine Release Syndrome / Immunologic Factors Type of study: Observational study Limits: Humans Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cytokines / Coronavirus Infections / Sirolimus / Pandemics / Cytokine Release Syndrome / Immunologic Factors Type of study: Observational study Limits: Humans Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article