Decreased T cell populations contribute to the increased severity of COVID-19.
Clin Chim Acta
; 508: 110-114, 2020 Sep.
Article
in English
| MEDLINE | ID: covidwho-245497
ABSTRACT
BACKGROUND:
We observe changes of the main lymphocyte subsets (CD16+CD56ãCD19ãCD3ãCD4ãand CD8) in COVID-19-infected patients and explore whether the changes are associated with disease severity.METHODS:
One-hundred and fifty-four cases of COVID-19-infected patients were selected and divided into 3 groups (moderate group, severe group and critical group). The flow cytometry assay was performed to examine the numbers of lymphocyte subsets.RESULTS:
CD3+, CD4+ and CD8 + T lymphocyte subsets were decreased in COVID-19-infected patients. Compared with the moderate group and the sever group, CD3+, CD4+ and CD8+ T cells in the critical group decreased greatly (P < 0.001, P = 0.005 or P = 0.001).CONCLUSIONS:
Reduced CD3+, CD4+, CD8+ T lymphocyte counts may reflect the severity of the COVID-19. Monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Cardiovascular Diseases
/
T-Lymphocyte Subsets
/
Coronavirus Infections
/
Diabetes Mellitus
/
Betacoronavirus
/
Lung Diseases
Type of study:
Cohort study
/
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Language:
English
Journal:
Clin Chim Acta
Year:
2020
Document Type:
Article
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