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Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy.
Goyal, Bhupesh; Goyal, Deepti.
  • Goyal B; School of Chemistry & Biochemistry, Thapar Institute of Engineering & Technology, Patiala-147004, Punjab, India.
  • Goyal D; Department of Chemistry, Faculty of Basic and Applied Sciences, Sri Guru Granth Sahib World University, Fatehgarh Sahib-140406, Punjab, India.
ACS Comb Sci ; 22(6): 297-305, 2020 06 08.
Article in English | MEDLINE | ID: covidwho-247796
ABSTRACT
A new coronavirus (CoV) caused a pandemic named COVID-19, which has become a global health care emergency in the present time. The virus is referred to as SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) and has a genome similar (∼82%) to that of the previously known SARS-CoV (SARS coronavirus). An attractive therapeutic target for CoVs is the main protease (Mpro) or 3-chymotrypsin-like cysteine protease (3CLpro), as this enzyme plays a key role in polyprotein processing and is active in a dimeric form. Further, Mpro is highly conserved among various CoVs, and a mutation in Mpro is often lethal to the virus. Thus, drugs targeting the Mpro enzyme significantly reduce the risk of mutation-mediated drug resistance and display broad-spectrum antiviral activity. The combinatorial design of peptide-based inhibitors targeting the dimerization of SARS-CoV Mpro represents a potential therapeutic strategy. In this regard, we have compiled the literature reports highlighting the effect of mutations and N-terminal deletion of residues of SARS-CoV Mpro on its dimerization and, thus, catalytic activity. We believe that the present review will stimulate research in this less explored yet quite significant area. The effect of the COVID-19 epidemic and the possibility of future CoV outbreaks strongly emphasize the urgent need for the design and development of potent antiviral agents against CoV infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Protease Inhibitors / Cysteine Endopeptidases / Viral Nonstructural Proteins / Coronavirus Infections / Protein Multimerization / Betacoronavirus Type of study: Prognostic study Limits: Humans Language: English Journal: ACS Comb Sci Year: 2020 Document Type: Article Affiliation country: Acscombsci.0c00058

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Protease Inhibitors / Cysteine Endopeptidases / Viral Nonstructural Proteins / Coronavirus Infections / Protein Multimerization / Betacoronavirus Type of study: Prognostic study Limits: Humans Language: English Journal: ACS Comb Sci Year: 2020 Document Type: Article Affiliation country: Acscombsci.0c00058