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Hypoalbuminemia predicts the outcome of COVID-19 independent of age and co-morbidity.
Huang, Jiaofeng; Cheng, Aiguo; Kumar, Rahul; Fang, Yingying; Chen, Gongping; Zhu, Yueyong; Lin, Su.
  • Huang J; Department of Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Cheng A; Department of Critical Care, The Third People's Hospital of Yichang, Yichang, China.
  • Kumar R; Department of Gastroenterology and Hepatology, Changi General Hospital, Simei, Singapore.
  • Fang Y; Department of Tuberculosis, The Third People's Hospital of Yichang, Yichang, China.
  • Chen G; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Zhu Y; Department of Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Lin S; Department of Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
J Med Virol ; 92(10): 2152-2158, 2020 10.
Article in English | MEDLINE | ID: covidwho-260279
ABSTRACT
The coronavirus disease 2019 (COVID-19) has evolved into a pandemic rapidly. Most of the literature show that the elevated liver enzymes in COVID-19 are of little clinical significance. Lower albumin level is seen in severe COVID-19 and is not parallel to the changes in alanine aminotransferase and aspartate aminotransferase levels. We aimed to explore the impact of hypoalbuminemia in COVID-19. This retrospective cohort study included adult patients with confirmed COVID-19. The relationship between hypoalbuminemia and death was studied using binary logistic analysis. A total of 299 adult patients were included, 160 (53.5%) were males and the average age was 53.4 ± 16.7 years. The median time from the onset of illness to admission was 3 days (interquartile ranges, 2-5). Approximately one-third of the patients had comorbidities. Hypoalbuminemia (<35 g/L) was found in 106 (35.5%) patients. The difference in albumin was considerable between survivors and non-survivors (37.6 ± 6.2 vs 30.5 ± 4.0, P < .001). Serum albumin level was inversely correlated to white blood cell (r = -.149, P = .01) and neutrophil to lymphocyte ratio (r = -.298, P < .001). Multivariate analysis showed the presence of comorbidities (OR, 6.816; 95% CI, 1.361-34.133), lymphopenia (OR, 13.130; 95% CI, 1.632-105.658) and hypoalbuminemia (OR, 6.394; 95% CI, 1.315-31.092) were independent predictive factors for mortality. In conclusion, hypoalbuminemia is associated with the outcome of COVID-19. The potential therapeutic value of albumin infusion in COVID-19 should be further explored at the earliest.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hypoalbuminemia / COVID-19 / Hospitalization Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Med Virol Year: 2020 Document Type: Article Affiliation country: Jmv.26003

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hypoalbuminemia / COVID-19 / Hospitalization Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Med Virol Year: 2020 Document Type: Article Affiliation country: Jmv.26003