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Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19.
Fu, Jiewen; Zhou, Baixu; Zhang, Lianmei; Balaji, Kyathegowdanadoddi Srinivasa; Wei, Chunli; Liu, Xiaoyan; Chen, Hanchun; Peng, Jiangzhou; Fu, Junjiang.
  • Fu J; Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
  • Zhou B; Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
  • Zhang L; Department of Gynecology and Obstetrics, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.
  • Balaji KS; Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
  • Wei C; Department of Pathology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.
  • Liu X; Post Graduation Department of Studies and Research in Biotechnology, Teresian Research Center, Teresian College (Affiliated to University of Mysore), Siddhartha Nagara, Mysore, Karnataka, 570011, India.
  • Chen H; Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
  • Peng J; Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
  • Fu J; Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha, 410013, China.
Mol Biol Rep ; 47(6): 4383-4392, 2020 Jun.
Article in English | MEDLINE | ID: covidwho-260333
Semantic information from SemMedBD (by NLM)
1. receptor PART_OF 2019 novel coronavirus
Subject
receptor
Predicate
PART_OF
Object
2019 novel coronavirus
2. Clinical Significance PROCESS_OF Homo sapiens
Subject
Clinical Significance
Predicate
PROCESS_OF
Object
Homo sapiens
3. Body tissue PART_OF House mice
Subject
Body tissue
Predicate
PART_OF
Object
House mice
4. Body tissue PART_OF Malignant Neoplasms
Subject
Body tissue
Predicate
PART_OF
Object
Malignant Neoplasms
5. Kidney LOCATION_OF Immunohistochemistry
Subject
Kidney
Predicate
LOCATION_OF
Object
Immunohistochemistry
6. Body tissue LOCATION_OF Immunohistochemistry
Subject
Body tissue
Predicate
LOCATION_OF
Object
Immunohistochemistry
7. Kidney LOCATION_OF ACE2 gene|ACE2
Subject
Kidney
Predicate
LOCATION_OF
Object
ACE2 gene|ACE2
8. Testis LOCATION_OF ACE2 gene|ACE2
Subject
Testis
Predicate
LOCATION_OF
Object
ACE2 gene|ACE2
9. Female breast LOCATION_OF ACE2 gene|ACE2
Subject
Female breast
Predicate
LOCATION_OF
Object
ACE2 gene|ACE2
10. 2019 novel coronavirus CAUSES Infertility
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
Infertility
11. Testis LOCATION_OF High Level
Subject
Testis
Predicate
LOCATION_OF
Object
High Level
12. Cardiovascular LOCATION_OF High Level
Subject
Cardiovascular
Predicate
LOCATION_OF
Object
High Level
13. ACE2 gene|ACE2 ASSOCIATED_WITH Adult Liver Carcinoma
Subject
ACE2 gene|ACE2
Predicate
ASSOCIATED_WITH
Object
Adult Liver Carcinoma
14. ACE2 gene|ACE2 ASSOCIATED_WITH Malignant neoplasm of kidney
Subject
ACE2 gene|ACE2
Predicate
ASSOCIATED_WITH
Object
Malignant neoplasm of kidney
15. ACE2 gene|ACE2 ASSOCIATED_WITH Neoplasms
Subject
ACE2 gene|ACE2
Predicate
ASSOCIATED_WITH
Object
Neoplasms
16. ACE2 gene|ACE2 ASSOCIATED_WITH Malignant Neoplasms
Subject
ACE2 gene|ACE2
Predicate
ASSOCIATED_WITH
Object
Malignant Neoplasms
17. receptor PART_OF 2019 novel coronavirus
Subject
receptor
Predicate
PART_OF
Object
2019 novel coronavirus
18. Clinical Significance PROCESS_OF Homo sapiens
Subject
Clinical Significance
Predicate
PROCESS_OF
Object
Homo sapiens
19. Body tissue PART_OF House mice
Subject
Body tissue
Predicate
PART_OF
Object
House mice
20. Body tissue PART_OF Malignant Neoplasms
Subject
Body tissue
Predicate
PART_OF
Object
Malignant Neoplasms
21. Kidney LOCATION_OF Immunohistochemistry
Subject
Kidney
Predicate
LOCATION_OF
Object
Immunohistochemistry
22. Body tissue LOCATION_OF Immunohistochemistry
Subject
Body tissue
Predicate
LOCATION_OF
Object
Immunohistochemistry
23. Kidney LOCATION_OF ACE2 gene|ACE2
Subject
Kidney
Predicate
LOCATION_OF
Object
ACE2 gene|ACE2
24. Testis LOCATION_OF ACE2 gene|ACE2
Subject
Testis
Predicate
LOCATION_OF
Object
ACE2 gene|ACE2
25. Female breast LOCATION_OF ACE2 gene|ACE2
Subject
Female breast
Predicate
LOCATION_OF
Object
ACE2 gene|ACE2
26. 2019 novel coronavirus CAUSES Infertility
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
Infertility
27. Testis LOCATION_OF High Level
Subject
Testis
Predicate
LOCATION_OF
Object
High Level
28. Cardiovascular LOCATION_OF High Level
Subject
Cardiovascular
Predicate
LOCATION_OF
Object
High Level
29. ACE2 gene|ACE2 ASSOCIATED_WITH Adult Liver Carcinoma
Subject
ACE2 gene|ACE2
Predicate
ASSOCIATED_WITH
Object
Adult Liver Carcinoma
30. ACE2 gene|ACE2 ASSOCIATED_WITH Malignant neoplasm of kidney
Subject
ACE2 gene|ACE2
Predicate
ASSOCIATED_WITH
Object
Malignant neoplasm of kidney
31. ACE2 gene|ACE2 ASSOCIATED_WITH Neoplasms
Subject
ACE2 gene|ACE2
Predicate
ASSOCIATED_WITH
Object
Neoplasms
32. ACE2 gene|ACE2 ASSOCIATED_WITH Malignant Neoplasms
Subject
ACE2 gene|ACE2
Predicate
ASSOCIATED_WITH
Object
Malignant Neoplasms
ABSTRACT
The ACE2 gene is a receptor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) for COVID-19 (coronavirus disease 2019). To analyze the expression profiles and clinical significances for this gene in humans, RNA-seq data representing 27 different tissues were analyzed using NCBI; total RNA was extracted from different tissues of mouse and semi-quantitative reverse transcriptional-polymerase chain reaction (Q-RT-PCR) was carried out. Immunohistochemistry expression profiles in normal tissues and cancer tissues and TCGA survival analysis in renal and liver cancer were conducted. ACE2 was highly conserved in different species. In normal tissues, ACE2 expression distributions were organ-specific, mainly in the kidney, male testis and female breast, and cardiovascular and gastrointestinal systems. High level of expression in testis, cardiovascular and gastrointestinal system indicated that SARS-CoV-2 might not only attack the lungs, but also affect other organs, particularly the testes, thus it may severely damage male sexual development for younger male and lead to infertility in an adult male, if he contracted COVID-19. On the other side, high expression of ACE2 was correlated with increased survival rate in renal and liver cancer, indicating that ACE2 is a prognostic marker in both renal cancer and liver cancers. Thus, the ACE2 is a functional receptor for SARS-CoV-2 and has a potential anti-tumor role in cancer. Taken together, this study may not only provide potential clues for further medical pathogenesis of COVID-19 and male fertility, but also indicate the clinical significance of the role of the ACE2 gene in cancer.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pneumonia, Viral / Receptors, Virus / Coronavirus Infections / Peptidyl-Dipeptidase A / Spike Glycoprotein, Coronavirus / Betacoronavirus / Kidney Neoplasms / Liver Neoplasms Subject: Pneumonia, Viral / Receptors, Virus / Coronavirus Infections / Peptidyl-Dipeptidase A / Spike Glycoprotein, Coronavirus / Betacoronavirus / Kidney Neoplasms / Liver Neoplasms Type of study: Diagnostic study / Prognostic study Language: English Journal: Mol Biol Rep Clinical aspect: Prognosis Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pneumonia, Viral / Receptors, Virus / Coronavirus Infections / Peptidyl-Dipeptidase A / Spike Glycoprotein, Coronavirus / Betacoronavirus / Kidney Neoplasms / Liver Neoplasms Subject: Pneumonia, Viral / Receptors, Virus / Coronavirus Infections / Peptidyl-Dipeptidase A / Spike Glycoprotein, Coronavirus / Betacoronavirus / Kidney Neoplasms / Liver Neoplasms Type of study: Diagnostic study / Prognostic study Language: English Journal: Mol Biol Rep Clinical aspect: Prognosis Year: 2020
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