Your browser doesn't support javascript.
SARS-CoV-2 infection in two patients following recent lung transplantation.
Koczulla, Rembert A; Sczepanski, Bernd; Koteczki, Adam; Kuhnert, Stefan; Hecker, Matthias; Askevold, Ingolf; Schneider, Christian; Michel, Sebastian; Kneidinger, Nikolaus.
  • Koczulla RA; Institute for Pulmonary Rehabilitation Research, Schoen Klinik Berchtesgadener Land, Schoenau am Koenigssee, Germany.
  • Sczepanski B; Department of Pulmonary Rehabilitation, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.
  • Koteczki A; Department of Internal Medicine, Division of Pulmonary Diseases, Philipps-University Marburg, Marburg, Germany.
  • Kuhnert S; Teaching Hospital, Paracelsus Medical University, Salzburg, Austria.
  • Hecker M; Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg and Schönau Königssee, Germany.
  • Askevold I; Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg and Schönau Königssee, Germany.
  • Schneider C; Department of Pulmonary Medicine, University of Giessen and Marburg Lung Center (UGMLC), University Hospital of Giessen, Justus-Liebig-University of Giessen, Giessen, Germany.
  • Michel S; Department of Pulmonary Medicine, University of Giessen and Marburg Lung Center (UGMLC), University Hospital of Giessen, Justus-Liebig-University of Giessen, Giessen, Germany.
  • Kneidinger N; Department of General and Thoracic Surgery, University Hospital of Giessen, Justus-Liebig-University of Giessen, Giessen, Germany.
Am J Transplant ; 20(10): 2928-2932, 2020 10.
Article in English | MEDLINE | ID: covidwho-268563
Semantic information from SemMedBD (by NLM)
1. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
2. COVID-19 AFFECTS Decreased Immunologic Activity [PE]
Subject
COVID-19
Predicate
AFFECTS
Object
Decreased Immunologic Activity [PE]
3. Therapeutic immunosuppression ADMINISTERED_TO Patients
Subject
Therapeutic immunosuppression
Predicate
ADMINISTERED_TO
Object
Patients
4. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
5. Screening procedure ADMINISTERED_TO Patients
Subject
Screening procedure
Predicate
ADMINISTERED_TO
Object
Patients
6. COVID-19 PROCESS_OF Woman
Subject
COVID-19
Predicate
PROCESS_OF
Object
Woman
7. Asymptomatic Infections PROCESS_OF Patients
Subject
Asymptomatic Infections
Predicate
PROCESS_OF
Object
Patients
8. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
9. Severe Acute Respiratory Syndrome PROCESS_OF Transplant Recipients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Transplant Recipients
10. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
11. COVID-19 AFFECTS Decreased Immunologic Activity [PE]
Subject
COVID-19
Predicate
AFFECTS
Object
Decreased Immunologic Activity [PE]
12. Therapeutic immunosuppression ADMINISTERED_TO Patients
Subject
Therapeutic immunosuppression
Predicate
ADMINISTERED_TO
Object
Patients
13. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
14. Screening procedure ADMINISTERED_TO Patients
Subject
Screening procedure
Predicate
ADMINISTERED_TO
Object
Patients
15. COVID-19 PROCESS_OF Woman
Subject
COVID-19
Predicate
PROCESS_OF
Object
Woman
16. Asymptomatic Infections PROCESS_OF Patients
Subject
Asymptomatic Infections
Predicate
PROCESS_OF
Object
Patients
17. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
18. Severe Acute Respiratory Syndrome PROCESS_OF Transplant Recipients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Transplant Recipients
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has become a global health problem with pandemic character. Lung transplant recipients may be particularly at risk due to the high degree of immunosuppression and the lung being the organ primarily affected by COVID-19. We describe a 16-year-old male and a 64-year-old female recently lung transplanted patients with COVID-19 during inpatient rehabilitation. Both patients were receiving triple immunosuppressive therapy and had no signs of allograft dysfunction. Both patients had close contact with a person who developed COVID-19 and were tested positive for SARS-CoV-2. Subsequently, both patients underwent systematic screening and SARS-CoV-2 was ultimately detected. Although the 16-year-old boy was completely asymptomatic, the 64-year-old woman developed only mild COVID-19. Immunosuppressive therapy was unchanged and no experimental treatment was initiated. No signs of graft involvement or dysfunction were noticed. In conclusion, our report of patients with asymptomatic SARS-CoV-2 infection and mild COVID-19, respectively, may indicate that lung transplant recipients are not per se at risk for severe COVID-19. Further observations and controlled trials are urgently needed to study SARS-CoV-2 infection in lung transplant recipients.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Antiviral Agents / Pneumonia, Viral / Lung Transplantation / Coronavirus Infections / Transplant Recipients / Betacoronavirus Subject: Antiviral Agents / Pneumonia, Viral / Lung Transplantation / Coronavirus Infections / Transplant Recipients / Betacoronavirus Type of study: Case report Language: English Journal: Am J Transplant Clinical aspect: Diagnosis / Etiology / Therapy Year: 2020

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Antiviral Agents / Pneumonia, Viral / Lung Transplantation / Coronavirus Infections / Transplant Recipients / Betacoronavirus Subject: Antiviral Agents / Pneumonia, Viral / Lung Transplantation / Coronavirus Infections / Transplant Recipients / Betacoronavirus Type of study: Case report Language: English Journal: Am J Transplant Clinical aspect: Diagnosis / Etiology / Therapy Year: 2020
...