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Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.
Chen, Weilie; Lan, Yun; Yuan, Xiaozhen; Deng, Xilong; Li, Yueping; Cai, Xiaoli; Li, Liya; He, Ruiying; Tan, Yizhou; Deng, Xizi; Gao, Ming; Tang, Guofang; Zhao, Lingzhai; Wang, Jinlin; Fan, Qinghong; Wen, Chunyan; Tong, Yuwei; Tang, Yangbo; Hu, Fengyu; Li, Feng; Tang, Xiaoping.
  • Chen W; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Lan Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Yuan X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Deng X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Li Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Cai X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Li L; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • He R; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Tan Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Deng X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Gao M; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Tang G; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Zhao L; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Wang J; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Fan Q; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Wen C; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Tong Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Tang Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Hu F; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Li F; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
  • Tang X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
Emerg Microbes Infect ; 9(1): 469-473, 2020.
Article in English | MEDLINE | ID: covidwho-2765
ABSTRACT
The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Emerg Microbes Infect Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Emerg Microbes Infect Year: 2020 Document Type: Article