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Viral loads in throat and anal swabs in children infected with SARS-CoV-2
Non-conventional | WHO COVID | ID: covidwho-291196
ABSTRACT
Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay on anal swabs was recently reported to be persistently positive even after throat testing was negative during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, data about the consistent performance of RT-PCR assay on throat and anal swabs remain limited in pediatric patients. Here, we retrospectively reviewed RT-PCR-testing results of 212 pediatric patients with suspected SARS-CoV-2 infection at Wuhan Children's Hospital. The diagnostic potential of these two types of specimens were showed significant difference (positive rate 78.2% on throat swabs vs. 52.6% on anal swabs, McNemar Test P=0.0091) and exhibited a weak positive consistency (Kappa value was 0.311, P<0.0001) in pediatric patients. Furthermore, viral loads detected on both throat and anal swabs also showed no significant difference (P = 0.9511) and correlation (Pearson r = 0.0434, P = 0.8406), and exhibited an inconsistent kinetic change through the course of SARS-CoV-2 infection. Besides, viral loads in the throat and anal swabs were correlated with different types of immune states, immune-reactive phase, and the resolution phase/immunologic tolerance, respectively. These findings revealed that RT-PCR-testing on throat and anal swabs showed significant difference for monitoring SARS-CoV-2 infection and correlated with different immune state in pediatric patients.
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Collection: Databases of international organizations Database: WHO COVID Type of study: Diagnostic study / Prognostic study Document Type: Non-conventional

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Collection: Databases of international organizations Database: WHO COVID Type of study: Diagnostic study / Prognostic study Document Type: Non-conventional