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The role of interleukin-6 in monitoring severe case of coronavirus disease 2019
Non-conventional | WHO COVID | ID: covidwho-306055
ABSTRACT
Abstract Progression to severe disease is a difficult problem in treating coronavirus disease 2019 (COVID-19). The purpose of this study is to explore changes in markers of severe disease in COVID-19 patients. 69 severe COVID-19 patients were included. Patients with severe disease showed significant lymphocytopenia. Elevated level of lactate dehydrogenase (LDH), C-reactive protein (CRP), ferritin and D-dimer was found in most severe cases. Baseline interleukin-6 (IL-6) was found to be associated with COVID-19 severity. Indeed, the significant increase of baseline IL-6 was positively correlated to the maximal body temperature during hospitalization and to the increased baseline of CRP, LDH, ferritin and D-dimer. High baseline IL-6 was also associated with more progressed chest computed tomography (CT) findings. Significant decrease in IL-6 and improved CT assessment was found in patients during recovery, while IL-6 was further increased in exacerbated patients. Collectively, our results suggest that the dynamic change in IL-6 can be used as a marker for disease monitoring in patients with severe COVID-19.
Full text: Available Collection: Databases of international organizations Database: WHO COVID Type of study: Prognostic study Document Type: Non-conventional

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Full text: Available Collection: Databases of international organizations Database: WHO COVID Type of study: Prognostic study Document Type: Non-conventional