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The role of interleukin-6 in monitoring severe case of coronavirus disease 2019.
Liu, Tao; Zhang, Jieying; Yang, Yuhui; Ma, Hong; Li, Zhenyu; Zhang, Jiaoyue; Cheng, Ji; Zhang, Xiaoyun; Zhao, Yanxia; Xia, Zihan; Zhang, Liling; Wu, Gang; Yi, Jianhua.
  • Liu T; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang J; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Yang Y; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Ma H; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Li Z; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang J; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Cheng J; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang X; Liver intensive care unit, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Zhao Y; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xia Z; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang L; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wu G; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Yi J; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
EMBO Mol Med ; 12(7): e12421, 2020 07 07.
Article in English | MEDLINE | ID: covidwho-306055
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Severe disorder PROCESS_OF Patients
Subject
Severe disorder
Predicate
PROCESS_OF
Object
Patients
3. interleukin-6 ASSOCIATED_WITH COVID-19
Subject
interleukin-6
Predicate
ASSOCIATED_WITH
Object
COVID-19
4. Ferritin STIMULATES interleukin-6
Subject
Ferritin
Predicate
STIMULATES
Object
interleukin-6
5. Fibrin fragment D STIMULATES interleukin-6
Subject
Fibrin fragment D
Predicate
STIMULATES
Object
interleukin-6
6. Symptom aggravating factors PROCESS_OF Patients
Subject
Symptom aggravating factors
Predicate
PROCESS_OF
Object
Patients
7. Evaluation procedure USES Chest CT
Subject
Evaluation procedure
Predicate
USES
Object
Chest CT
8. Patients LOCATION_OF interleukin-6
Subject
Patients
Predicate
LOCATION_OF
Object
interleukin-6
9. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
10. Severe disorder PROCESS_OF Patients
Subject
Severe disorder
Predicate
PROCESS_OF
Object
Patients
11. interleukin-6 ASSOCIATED_WITH COVID-19
Subject
interleukin-6
Predicate
ASSOCIATED_WITH
Object
COVID-19
12. Ferritin STIMULATES interleukin-6
Subject
Ferritin
Predicate
STIMULATES
Object
interleukin-6
13. Fibrin fragment D STIMULATES interleukin-6
Subject
Fibrin fragment D
Predicate
STIMULATES
Object
interleukin-6
14. Symptom aggravating factors PROCESS_OF Patients
Subject
Symptom aggravating factors
Predicate
PROCESS_OF
Object
Patients
15. Evaluation procedure USES Chest CT
Subject
Evaluation procedure
Predicate
USES
Object
Chest CT
16. Patients LOCATION_OF interleukin-6
Subject
Patients
Predicate
LOCATION_OF
Object
interleukin-6
ABSTRACT
Progression to severe disease is a difficult problem in treating coronavirus disease 2019 (COVID-19). The purpose of this study is to explore changes in markers of severe disease in COVID-19 patients. Sixty-nine severe COVID-19 patients were included. Patients with severe disease showed significant lymphocytopenia. Elevated level of lactate dehydrogenase (LDH), C-reactive protein (CRP), ferritin, and D-dimer was found in most severe cases. Baseline interleukin-6 (IL-6) was found to be associated with COVID-19 severity. Indeed, the significant increase of baseline IL-6 was positively correlated with the maximal body temperature during hospitalization and with the increased baseline of CRP, LDH, ferritin, and D-dimer. High baseline IL-6 was also associated with more progressed chest computed tomography (CT) findings. Significant decrease in IL-6 and improved CT assessment was found in patients during recovery, while IL-6 was further increased in exacerbated patients. Collectively, our results suggest that the dynamic change in IL-6 can be used as a marker for disease monitoring in patients with severe COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interleukin-6 / Coronavirus Infections Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: EMBO Mol Med Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: Emmm.202012421

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interleukin-6 / Coronavirus Infections Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: EMBO Mol Med Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: Emmm.202012421