Your browser doesn't support javascript.
Immunoinformatics-guided designing of epitope-based subunit vaccines against the SARS Coronavirus-2 (SARS-CoV-2).
Sarkar, Bishajit; Ullah, Md Asad; Johora, Fatema Tuz; Taniya, Masuma Afrin; Araf, Yusha.
  • Sarkar B; Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Jahangirnagar University, Dhaka, Bangladesh. Electronic address: sarkarbishajit@gmail.com.
  • Ullah MA; Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Jahangirnagar University, Dhaka, Bangladesh.
  • Johora FT; Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Jahangirnagar University, Dhaka, Bangladesh.
  • Taniya MA; Department of Microbiology, School of Life Sciences, Independent University, Dhaka, Bangladesh.
  • Araf Y; Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh.
Immunobiology ; 225(3): 151955, 2020 05.
Article in English | MEDLINE | ID: covidwho-309013
ABSTRACT
SARS Coronavirus-2 (SARS-CoV-2) pandemic has become a global issue which has raised the concern of scientific community to design and discover a counter-measure against this deadly virus. So far, the pandemic has caused the death of hundreds of thousands of people upon infection and spreading. To date, no effective vaccine is available which can combat the infection caused by this virus. Therefore, this study was conducted to design possible epitope-based subunit vaccines against the SARS-CoV-2 virus using the approaches of reverse vaccinology and immunoinformatics. Upon continual computational experimentation, three possible vaccine constructs were designed and one vaccine construct was selected as the best vaccine based on molecular docking study which is supposed to effectively act against the SARS-CoV-2. Thereafter, the molecular dynamics simulation and in silico codon adaptation experiments were carried out in order to check biological stability and find effective mass production strategy of the selected vaccine. This study should contribute to uphold the present efforts of the researches to secure a definitive preventative measure against this lethal disease.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Proteins / Viral Vaccines / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Observational study Topics: Vaccines Language: English Journal: Immunobiology Year: 2020 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Proteins / Viral Vaccines / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Observational study Topics: Vaccines Language: English Journal: Immunobiology Year: 2020 Document Type: Article