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Teicoplanin: an alternative drug for the treatment of COVID-19?
Baron, Sophie Alexandra; Devaux, Christian; Colson, Philippe; Raoult, Didier; Rolain, Jean-Marc.
  • Baron SA; Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
  • Devaux C; Aix-Marseille Université, IRD, APHM, VITROME, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
  • Colson P; Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
  • Raoult D; Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; IHU-Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
  • Rolain JM; Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; IHU-Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France. Electronic address: jean-marc.rolain@univ-amu.fr.
Int J Antimicrob Agents ; 55(4): 105944, 2020 Apr.
Article in English | MEDLINE | ID: covidwho-30948
ABSTRACT
In December 2019, a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged from China causing pneumonia outbreaks, first in the Wuhan region of China and then spread worldwide because of its probable high transmission efficiency. Owing to the lack of efficient and specific treatments and the need to contain the epidemic, drug repurposing appears to be the best tool to find a therapeutic solution. Chloroquine, remdesivir, lopinavir, ribavirin and ritonavir have shown efficacy to inhibit coronavirus in vitro. Teicoplanin, an antibiotic used to treat staphylococcal infections, previously showed efficacy to inhibit the first stage of the Middle East respiratory syndrome coronavirus (MERS-CoV) viral life cycle in human cells. This activity is conserved against SARS-Cov-2, thus placing teicoplanin as a potential treatment for patients with this virus.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Teicoplanin / Coronavirus Infections Limits: Humans Language: English Journal: Int J Antimicrob Agents Year: 2020 Document Type: Article Affiliation country: J.ijantimicag.2020.105944

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Teicoplanin / Coronavirus Infections Limits: Humans Language: English Journal: Int J Antimicrob Agents Year: 2020 Document Type: Article Affiliation country: J.ijantimicag.2020.105944