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Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019-Induced Acute Respiratory Distress Syndrome: A Multicenter Descriptive Study.
Yang, Xiao; Cai, Shuhan; Luo, Yun; Zhu, Fangfang; Hu, Ming; Zhao, Yan; Zheng, Ruiqiang; Li, Xuyan; Hu, Bo; Peng, Zhiyong.
  • Yang X; Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Cai S; Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Luo Y; Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Zhu F; Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Hu M; Department of Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, Hubei, China.
  • Zhao Y; Department of Emergency Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Zheng R; Department of Critical Care Medicine, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu Province, China.
  • Li X; Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
  • Hu B; Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Peng Z; Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Crit Care Med ; 48(9): 1289-1295, 2020 09.
Article in English | MEDLINE | ID: covidwho-317610
Semantic information from SemMedBD (by NLM)
1. COVID-19 CAUSES Respiratory Distress Syndrom
Subject
COVID-19
Predicate
CAUSES
Object
Respiratory Distress Syndrom
2. Severe Acute Respiratory Syndrome COMPLICATES COVID-19
Subject
Severe Acute Respiratory Syndrome
Predicate
COMPLICATES
Object
COVID-19
3. Extracorporeal Membrane Oxygenation ADMINISTERED_TO Patients
Subject
Extracorporeal Membrane Oxygenation
Predicate
ADMINISTERED_TO
Object
Patients
4. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
5. Hospitals LOCATION_OF Study
Subject
Hospitals
Predicate
LOCATION_OF
Object
Study
6. Extracorporeal Membrane Oxygenation TREATS Pneumonia
Subject
Extracorporeal Membrane Oxygenation
Predicate
TREATS
Object
Pneumonia
7. Extracorporeal Membrane Oxygenation TREATS Patients
Subject
Extracorporeal Membrane Oxygenation
Predicate
TREATS
Object
Patients
8. Mechanical ventilation ADMINISTERED_TO Patients
Subject
Mechanical ventilation
Predicate
ADMINISTERED_TO
Object
Patients
9. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
10. Extracorporeal Membrane Oxygenation TREATS Survivors
Subject
Extracorporeal Membrane Oxygenation
Predicate
TREATS
Object
Survivors
11. 2019 novel coronavirus PROCESS_OF Patients
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Patients
12. COVID-19 CAUSES Respiratory Distress Syndrome, Adult
Subject
COVID-19
Predicate
CAUSES
Object
Respiratory Distress Syndrome, Adult
13. Severe Acute Respiratory Syndrome COMPLICATES COVID-19
Subject
Severe Acute Respiratory Syndrome
Predicate
COMPLICATES
Object
COVID-19
14. Extracorporeal Membrane Oxygenation ADMINISTERED_TO Patients
Subject
Extracorporeal Membrane Oxygenation
Predicate
ADMINISTERED_TO
Object
Patients
15. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
16. Hospitals LOCATION_OF Study
Subject
Hospitals
Predicate
LOCATION_OF
Object
Study
17. Extracorporeal Membrane Oxygenation TREATS Pneumonia
Subject
Extracorporeal Membrane Oxygenation
Predicate
TREATS
Object
Pneumonia
18. Extracorporeal Membrane Oxygenation TREATS Patients
Subject
Extracorporeal Membrane Oxygenation
Predicate
TREATS
Object
Patients
19. Mechanical ventilation ADMINISTERED_TO Patients
Subject
Mechanical ventilation
Predicate
ADMINISTERED_TO
Object
Patients
20. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
21. Extracorporeal Membrane Oxygenation TREATS Survivors
Subject
Extracorporeal Membrane Oxygenation
Predicate
TREATS
Object
Survivors
22. 2019 novel coronavirus PROCESS_OF Patients
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

OBJECTIVES:

Severe acute respiratory distress syndrome is complicated with coronavirus disease 2019 and extracorporeal membrane oxygenation support may be necessary in severe cases. This study is to summarize the clinical features, extracorporeal membrane oxygenation characteristics, and outcomes of patients with severe acute respiratory syndrome coronavirus 2 pneumonia received extracorporeal membrane oxygenation.

DESIGN:

Descriptive study from two hospitals.

SETTING:

The ICUs from university hospitals. PATIENTS Patients with severe acute respiratory syndrome coronavirus 2 pneumonia received mechanical ventilation, including those underwent extracorporeal membrane oxygenation from Zhongnan Hospital of Wuhan University and Wuhan Pulmonary Hospital from January 8, 2020, to March 31, 2020.

INTERVENTIONS:

None. MEASUREMENTS AND MAIN

RESULTS:

Clinical records, laboratory results, ventilator parameters, and extracorporeal membrane oxygenation-related data were abstracted from the medical records. One-hundred twenty-nine critically ill patients with severe acute respiratory syndrome coronavirus 2 pneumonia were admitted to ICU of the two referral hospitals. Fifty-nine patients received mechanical ventilation and 21 of them received extracorporeal membrane oxygenation support (fourteen from Zhongnan hospital and seven from Wuhan pulmonary hospital). Compared to mechanical ventilation patients without extracorporeal membrane oxygenation support, there was a tendency of decline in mortality but with no significant difference (no-extracorporeal membrane oxygenation group 24/38 [63.2%] vs extracorporeal membrane oxygenation group 12/21 [57.1%]; p = 0.782). For those patients with extracorporeal membrane oxygenation, 12 patients died and nine survived by April 7, 2020. Among extracorporeal membrane oxygenation patients, the PaCO2 prior to extracorporeal membrane oxygenation was lower (54.40 mm Hg [29.20-57.50 mm Hg] vs 63.20 mm Hg [55.40-72.12 mm Hg]; p = 0.006), and pH prior to extracorporeal membrane oxygenation was higher (7.38 [7.28-7.48] vs 7.23 [7.16-7.33]; p = 0.023) in survivors than nonsurvivors.

CONCLUSIONS:

Extracorporeal membrane oxygenation might be an effective salvage treatment for patients with severe acute respiratory syndrome coronavirus 2 pneumonia associated with severe acute respiratory distress syndrome. Severe CO2 retention and acidosis prior to extracorporeal membrane oxygenation indicated a poor prognosis.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Respiratory Distress Syndrome / Extracorporeal Membrane Oxygenation / Coronavirus Infections / Betacoronavirus Type of study: Controlled clinical trial / Diagnostic study / Etiology study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Crit Care Med Year: 2020 Document Type: Article Affiliation country: CCM.0000000000004447

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Respiratory Distress Syndrome / Extracorporeal Membrane Oxygenation / Coronavirus Infections / Betacoronavirus Type of study: Controlled clinical trial / Diagnostic study / Etiology study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Crit Care Med Year: 2020 Document Type: Article Affiliation country: CCM.0000000000004447