IL-6: Relevance for immunopathology of SARS-CoV-2.
Cytokine Growth Factor Rev
; 53: 13-24, 2020 06.
Article
in English
| MEDLINE | ID: covidwho-324437
ABSTRACT
COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in cytokine release syndrome and multiorgan failure. It is becoming critically important to identify at the early stage of the infection those patients who are prone to develop the most adverse effects. Elevated systemic interleukin-6 levels in patients with COVID-19 are considered as a relevant parameter in predicting most severe course of disease and the need for intensive care. This review discusses the mechanisms by which IL-6 may possibly contribute to disease exacerbation and the potential of therapeutic approaches based on anti-IL-6 biologics.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Interleukin-6
/
Coronavirus Infections
/
Antibodies, Monoclonal, Humanized
/
Cytokine Release Syndrome
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Cytokine Growth Factor Rev
Journal subject:
Allergy and Immunology
/
Biochemistry
Year:
2020
Document Type:
Article
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