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SARS-CoV-2 infection protects against rechallenge in rhesus macaques.
Chandrashekar, Abishek; Liu, Jinyan; Martinot, Amanda J; McMahan, Katherine; Mercado, Noe B; Peter, Lauren; Tostanoski, Lisa H; Yu, Jingyou; Maliga, Zoltan; Nekorchuk, Michael; Busman-Sahay, Kathleen; Terry, Margaret; Wrijil, Linda M; Ducat, Sarah; Martinez, David R; Atyeo, Caroline; Fischinger, Stephanie; Burke, John S; Slein, Matthew D; Pessaint, Laurent; Van Ry, Alex; Greenhouse, Jack; Taylor, Tammy; Blade, Kelvin; Cook, Anthony; Finneyfrock, Brad; Brown, Renita; Teow, Elyse; Velasco, Jason; Zahn, Roland; Wegmann, Frank; Abbink, Peter; Bondzie, Esther A; Dagotto, Gabriel; Gebre, Makda S; He, Xuan; Jacob-Dolan, Catherine; Kordana, Nicole; Li, Zhenfeng; Lifton, Michelle A; Mahrokhian, Shant H; Maxfield, Lori F; Nityanandam, Ramya; Nkolola, Joseph P; Schmidt, Aaron G; Miller, Andrew D; Baric, Ralph S; Alter, Galit; Sorger, Peter K; Estes, Jacob D.
  • Chandrashekar A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Liu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Martinot AJ; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • McMahan K; Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.
  • Mercado NB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Peter L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Tostanoski LH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Yu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Maliga Z; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Nekorchuk M; Harvard Medical School, Boston, MA 02115, USA.
  • Busman-Sahay K; Oregon Health & Sciences University, Beaverton, OR 97006, USA.
  • Terry M; Oregon Health & Sciences University, Beaverton, OR 97006, USA.
  • Wrijil LM; Oregon Health & Sciences University, Beaverton, OR 97006, USA.
  • Ducat S; Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.
  • Martinez DR; Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.
  • Atyeo C; University of North Carolina, Chapel Hill, NC 27599, USA.
  • Fischinger S; Harvard Medical School, Boston, MA 02115, USA.
  • Burke JS; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Slein MD; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Pessaint L; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Van Ry A; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Greenhouse J; Bioqual, Rockville, MD 20852, USA.
  • Taylor T; Bioqual, Rockville, MD 20852, USA.
  • Blade K; Bioqual, Rockville, MD 20852, USA.
  • Cook A; Bioqual, Rockville, MD 20852, USA.
  • Finneyfrock B; Bioqual, Rockville, MD 20852, USA.
  • Brown R; Bioqual, Rockville, MD 20852, USA.
  • Teow E; Bioqual, Rockville, MD 20852, USA.
  • Velasco J; Bioqual, Rockville, MD 20852, USA.
  • Zahn R; Bioqual, Rockville, MD 20852, USA.
  • Wegmann F; Bioqual, Rockville, MD 20852, USA.
  • Abbink P; Janssen Vaccines & Prevention BV, Leiden, Netherlands.
  • Bondzie EA; Janssen Vaccines & Prevention BV, Leiden, Netherlands.
  • Dagotto G; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Gebre MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • He X; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Jacob-Dolan C; Harvard Medical School, Boston, MA 02115, USA.
  • Kordana N; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Li Z; Harvard Medical School, Boston, MA 02115, USA.
  • Lifton MA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Mahrokhian SH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Maxfield LF; Harvard Medical School, Boston, MA 02115, USA.
  • Nityanandam R; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Nkolola JP; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Schmidt AG; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Miller AD; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Baric RS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Alter G; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Sorger PK; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Estes JD; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Science ; 369(6505): 812-817, 2020 08 14.
Article in English | MEDLINE | ID: covidwho-327276
Semantic information from SemMedBD (by NLM)
1. Severe Acute Respiratory Syndrome PROCESS_OF Macaca mulatta
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Macaca mulatta
2. Immunity PROCESS_OF Nonhuman primate
Subject
Immunity
Predicate
PROCESS_OF
Object
Nonhuman primate
3. Severe Acute Respiratory Syndrome PROCESS_OF Macaca mulatta
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Macaca mulatta
4. Immunity PROCESS_OF Nonhuman primate
Subject
Immunity
Predicate
PROCESS_OF
Object
Nonhuman primate
ABSTRACT
An understanding of protective immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for vaccine and public health strategies aimed at ending the global coronavirus disease 2019 (COVID-19) pandemic. A key unanswered question is whether infection with SARS-CoV-2 results in protective immunity against reexposure. We developed a rhesus macaque model of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower respiratory tract, humoral and cellular immune responses, and pathologic evidence of viral pneumonia. After the initial viral clearance, animals were rechallenged with SARS-CoV-2 and showed 5 log10 reductions in median viral loads in bronchoalveolar lavage and nasal mucosa compared with after the primary infection. Anamnestic immune responses after rechallenge suggested that protection was mediated by immunologic control. These data show that SARS-CoV-2 infection induced protective immunity against reexposure in nonhuman primates.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Topics: Vaccines Language: English Journal: Science Year: 2020 Document Type: Article Affiliation country: Science.abc4776

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Topics: Vaccines Language: English Journal: Science Year: 2020 Document Type: Article Affiliation country: Science.abc4776